Abstract
Background: Docosahexaenoic acid (DHA, 22:6n-3) supplementation in the prenatal period is associated with a reduction in the incidence of some symptoms of allergic disease. Infants born preterm are at increased risk of allergic disease, but it is unknown if DHA supplementation reduces the risk of childhood allergies. Objectives: The aim of this study was to determine if supplementation of infants born at >33 wk gestation with high-DHA compared with standard-DHA enteral feeds decreases the incidence and severity of parent-reported allergic disease symptoms at a corrected age (CA) of 7 y. Methods: This study was a follow-up of an Australian multicenter randomized controlled trial. Infants were given high-DHA (-1% total fatty acids) or standard-DHA (-0.3% total fatty acids) enteral feeds from 2-4 d of postnatal age until 40 wk postmenstrual age. Parent-reported incidence of respiratory allergic disease symptoms including wheeze and rhinitis at 7 y CA were the main outcomes. Other outcomes included the incidence of eczema symptoms; severity of any symptoms; and the incidence of wheeze, rhinitis, rhinoconjunctivitis, and eczema from birth to 7 y CA. Results: Data were available for 569 of 657 (87%) children originally randomized. Symptoms of wheeze or rhinitis at 7 y CA did not differ between high-and standard-DHA groups [wheeze: RR: 1.10; 95% CI: 0.73, 1.65; P = 0.66; rhinitis: RR: 1.09; 95% CI: 0.81, 1.46; P = 0.59]. There was no difference in other allergic disease symptoms at 7 y CA or in the severity of symptoms. Parent-reported symptoms of wheeze, rhinitis, rhinoconjunctivitis, or eczema from birth to 7 y CA did not differ between the groups. Conclusions: High-dose DHA supplementation of infants born at >33 wk gestation did not alter allergic disease symptoms or severity at 7 y CA, or from birth to 7 y CA compared with standard-dose DHA.
| Language | English |
|---|---|
| Pages | 1600-1610 |
| Number of pages | 11 |
| Journal | American Journal of Clinical Nutrition |
| Volume | 109 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1 Jun 2019 |
Keywords
- ?-3 Long-Chain Polyunsaturated Fatty Acids
- Allergic Disease
- Docosahexaenoic Acid
- Prematurity
- Preterm Infant
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
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Docosahexaenoic acid supplementation of preterm infants and parent-reported symptoms of allergic disease at 7 years corrected age : Follow-up of a randomized controlled trial. / Gunaratne, Anoja W.; Makrides, Maria; Collins, Carmel; Gibson, Robert; McPhee, Andrew; Sullivan, Thomas; Gould, Jacqueline; Green, Tim; Doyle, Lex W.; Davis, Peter G.; French, Noel P.; Colditz, Paul B.; Simmer, Karen; Morris, Scott A.; Best, Karen.
In: American Journal of Clinical Nutrition, Vol. 109, No. 6, 01.06.2019, p. 1600-1610.Research output: Contribution to journal › Article
TY - JOUR
T1 - Docosahexaenoic acid supplementation of preterm infants and parent-reported symptoms of allergic disease at 7 years corrected age
T2 - American Journal of Clinical Nutrition
AU - Gunaratne, Anoja W.
AU - Makrides, Maria
AU - Collins, Carmel
AU - Gibson, Robert
AU - McPhee, Andrew
AU - Sullivan, Thomas
AU - Gould, Jacqueline
AU - Green, Tim
AU - Doyle, Lex W.
AU - Davis, Peter G.
AU - French, Noel P.
AU - Colditz, Paul B.
AU - Simmer, Karen
AU - Morris, Scott A.
AU - Best, Karen
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Background: Docosahexaenoic acid (DHA, 22:6n-3) supplementation in the prenatal period is associated with a reduction in the incidence of some symptoms of allergic disease. Infants born preterm are at increased risk of allergic disease, but it is unknown if DHA supplementation reduces the risk of childhood allergies. Objectives: The aim of this study was to determine if supplementation of infants born at >33 wk gestation with high-DHA compared with standard-DHA enteral feeds decreases the incidence and severity of parent-reported allergic disease symptoms at a corrected age (CA) of 7 y. Methods: This study was a follow-up of an Australian multicenter randomized controlled trial. Infants were given high-DHA (-1% total fatty acids) or standard-DHA (-0.3% total fatty acids) enteral feeds from 2-4 d of postnatal age until 40 wk postmenstrual age. Parent-reported incidence of respiratory allergic disease symptoms including wheeze and rhinitis at 7 y CA were the main outcomes. Other outcomes included the incidence of eczema symptoms; severity of any symptoms; and the incidence of wheeze, rhinitis, rhinoconjunctivitis, and eczema from birth to 7 y CA. Results: Data were available for 569 of 657 (87%) children originally randomized. Symptoms of wheeze or rhinitis at 7 y CA did not differ between high-and standard-DHA groups [wheeze: RR: 1.10; 95% CI: 0.73, 1.65; P = 0.66; rhinitis: RR: 1.09; 95% CI: 0.81, 1.46; P = 0.59]. There was no difference in other allergic disease symptoms at 7 y CA or in the severity of symptoms. Parent-reported symptoms of wheeze, rhinitis, rhinoconjunctivitis, or eczema from birth to 7 y CA did not differ between the groups. Conclusions: High-dose DHA supplementation of infants born at >33 wk gestation did not alter allergic disease symptoms or severity at 7 y CA, or from birth to 7 y CA compared with standard-dose DHA.
AB - Background: Docosahexaenoic acid (DHA, 22:6n-3) supplementation in the prenatal period is associated with a reduction in the incidence of some symptoms of allergic disease. Infants born preterm are at increased risk of allergic disease, but it is unknown if DHA supplementation reduces the risk of childhood allergies. Objectives: The aim of this study was to determine if supplementation of infants born at >33 wk gestation with high-DHA compared with standard-DHA enteral feeds decreases the incidence and severity of parent-reported allergic disease symptoms at a corrected age (CA) of 7 y. Methods: This study was a follow-up of an Australian multicenter randomized controlled trial. Infants were given high-DHA (-1% total fatty acids) or standard-DHA (-0.3% total fatty acids) enteral feeds from 2-4 d of postnatal age until 40 wk postmenstrual age. Parent-reported incidence of respiratory allergic disease symptoms including wheeze and rhinitis at 7 y CA were the main outcomes. Other outcomes included the incidence of eczema symptoms; severity of any symptoms; and the incidence of wheeze, rhinitis, rhinoconjunctivitis, and eczema from birth to 7 y CA. Results: Data were available for 569 of 657 (87%) children originally randomized. Symptoms of wheeze or rhinitis at 7 y CA did not differ between high-and standard-DHA groups [wheeze: RR: 1.10; 95% CI: 0.73, 1.65; P = 0.66; rhinitis: RR: 1.09; 95% CI: 0.81, 1.46; P = 0.59]. There was no difference in other allergic disease symptoms at 7 y CA or in the severity of symptoms. Parent-reported symptoms of wheeze, rhinitis, rhinoconjunctivitis, or eczema from birth to 7 y CA did not differ between the groups. Conclusions: High-dose DHA supplementation of infants born at >33 wk gestation did not alter allergic disease symptoms or severity at 7 y CA, or from birth to 7 y CA compared with standard-dose DHA.
KW - ?-3 Long-Chain Polyunsaturated Fatty Acids
KW - Allergic Disease
KW - Docosahexaenoic Acid
KW - Prematurity
KW - Preterm Infant
UR - http://www.scopus.com/inward/record.url?scp=85067270434&partnerID=8YFLogxK
U2 - 10.1093/ajcn/nqz010
DO - 10.1093/ajcn/nqz010
M3 - Article
VL - 109
SP - 1600
EP - 1610
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 6
ER -