Discovery of α-defensins in basal mammals

David J. Lynn, Daniel G. Bradley

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

α-Defensins are essential molecules of the innate immune system that have broad spectrum antimicrobial activity against a range of bacteria and viruses. To date, α-defensins have only been identified in the Euarchontoglires branch of the mammals. This has led to speculation that α-defensins may be specific to this group, a somewhat surprising finding, given their importance in the immune system. The mammalian genome project provided us with the opportunity to search for α-defensins in previously unexamined mammalian superorders. Using hidden Markov model (HMM) profile searching, we report the discovery of α-defensins in the African savanna elephant, the lesser hedgehog tenrec, and the nine-banded armadillo genomes representing two of the most basal mammalian superorders, Afrotheria and Xenarthra. Furthermore, we identify an α-defensin-like gene in the gray short-tailed opossum, suggesting that α-defensins may have evolved much earlier than previously thought, before the divergence of placental mammals and marsupials approximately 130 mya.

Original languageEnglish
Pages (from-to)963-967
Number of pages5
JournalDevelopmental and Comparative Immunology
Volume31
Issue number10
DOIs
Publication statusPublished - 2007

Keywords

  • Armadillo
  • Elephant
  • Evolution
  • Hidden Markov model profile
  • Mammal
  • Opossum
  • Tenrec
  • α-Defensins

ASJC Scopus subject areas

  • Immunology
  • Developmental Biology

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