Differential modulation of motor cortex excitability in BDNF Met allele carriers following experimentally induced and use-dependent plasticity

John Cirillo, James Hughes, Michael Ridding, Paul Thomas, John G. Semmler

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The purpose of this study was to investigate how healthy young subjects with one of three variants of the brain-derived neurotrophic factor (BDNF) gene modulate motor cortex excitability following experimentally induced and use-dependent plasticity interventions. Electromyographic recordings were obtained from the right first dorsal interosseous (FDI) muscle of 12Val/Val, ten Val/Met and seven Met/Met genotypes (aged 18-39years). Transcranial magnetic stimulation of the left hemisphere was used to assess changes in FDI motor-evoked potentials (MEPs) following three separate interventions involving paired associative stimulation, a simple ballistic task and complex visuomotor tracking task using the index finger. Val/Val subjects increased FDI MEPs following all interventions (≥25%, P<0.01), whereas the Met allele carriers only showed increased MEPs after the simple motor task (≥26%, P<0.01). In contrast to the simple motor task, there was no significant change in MEPs for the Val/Met subjects (7%, P=0.50) and a reduction in MEPs for the Met/Met group (-38%, P<0.01) following the complex motor task. Despite these differences in use-dependent plasticity, the performance of both motor tasks was not different between BDNF genotypes. We conclude that modulation of motor cortex excitability is strongly influenced by the BDNF polymorphism, with the greatest differences observed for the complex motor task. We also found unique motor cortex plasticity in the rarest form of the BDNF polymorphism (Met/Met subjects), which may have implications for functional recovery after disease or injury to the nervous system in these individuals.

LanguageEnglish
Pages2640-2649
Number of pages10
JournalEuropean Journal of Neuroscience
Volume36
Issue number5
DOIs
Publication statusPublished - 1 Sep 2012
Externally publishedYes

Keywords

  • BDNF polymorphism
  • Motor cortex
  • Motor skill
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

@article{4fcd873da8ac4ebfb24918ae0c8d9832,
title = "Differential modulation of motor cortex excitability in BDNF Met allele carriers following experimentally induced and use-dependent plasticity",
abstract = "The purpose of this study was to investigate how healthy young subjects with one of three variants of the brain-derived neurotrophic factor (BDNF) gene modulate motor cortex excitability following experimentally induced and use-dependent plasticity interventions. Electromyographic recordings were obtained from the right first dorsal interosseous (FDI) muscle of 12Val/Val, ten Val/Met and seven Met/Met genotypes (aged 18-39years). Transcranial magnetic stimulation of the left hemisphere was used to assess changes in FDI motor-evoked potentials (MEPs) following three separate interventions involving paired associative stimulation, a simple ballistic task and complex visuomotor tracking task using the index finger. Val/Val subjects increased FDI MEPs following all interventions (≥25{\%}, P<0.01), whereas the Met allele carriers only showed increased MEPs after the simple motor task (≥26{\%}, P<0.01). In contrast to the simple motor task, there was no significant change in MEPs for the Val/Met subjects (7{\%}, P=0.50) and a reduction in MEPs for the Met/Met group (-38{\%}, P<0.01) following the complex motor task. Despite these differences in use-dependent plasticity, the performance of both motor tasks was not different between BDNF genotypes. We conclude that modulation of motor cortex excitability is strongly influenced by the BDNF polymorphism, with the greatest differences observed for the complex motor task. We also found unique motor cortex plasticity in the rarest form of the BDNF polymorphism (Met/Met subjects), which may have implications for functional recovery after disease or injury to the nervous system in these individuals.",
keywords = "BDNF polymorphism, Motor cortex, Motor skill, Transcranial magnetic stimulation",
author = "John Cirillo and James Hughes and Michael Ridding and Paul Thomas and Semmler, {John G.}",
year = "2012",
month = "9",
day = "1",
doi = "10.1111/j.1460-9568.2012.08177.x",
language = "English",
volume = "36",
pages = "2640--2649",
journal = "European Journal of Neuroscience",
issn = "0953-816X",
publisher = "Wiley-Blackwell",
number = "5",

}

Differential modulation of motor cortex excitability in BDNF Met allele carriers following experimentally induced and use-dependent plasticity. / Cirillo, John; Hughes, James; Ridding, Michael; Thomas, Paul; Semmler, John G.

In: European Journal of Neuroscience, Vol. 36, No. 5, 01.09.2012, p. 2640-2649.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Differential modulation of motor cortex excitability in BDNF Met allele carriers following experimentally induced and use-dependent plasticity

AU - Cirillo, John

AU - Hughes, James

AU - Ridding, Michael

AU - Thomas, Paul

AU - Semmler, John G.

PY - 2012/9/1

Y1 - 2012/9/1

N2 - The purpose of this study was to investigate how healthy young subjects with one of three variants of the brain-derived neurotrophic factor (BDNF) gene modulate motor cortex excitability following experimentally induced and use-dependent plasticity interventions. Electromyographic recordings were obtained from the right first dorsal interosseous (FDI) muscle of 12Val/Val, ten Val/Met and seven Met/Met genotypes (aged 18-39years). Transcranial magnetic stimulation of the left hemisphere was used to assess changes in FDI motor-evoked potentials (MEPs) following three separate interventions involving paired associative stimulation, a simple ballistic task and complex visuomotor tracking task using the index finger. Val/Val subjects increased FDI MEPs following all interventions (≥25%, P<0.01), whereas the Met allele carriers only showed increased MEPs after the simple motor task (≥26%, P<0.01). In contrast to the simple motor task, there was no significant change in MEPs for the Val/Met subjects (7%, P=0.50) and a reduction in MEPs for the Met/Met group (-38%, P<0.01) following the complex motor task. Despite these differences in use-dependent plasticity, the performance of both motor tasks was not different between BDNF genotypes. We conclude that modulation of motor cortex excitability is strongly influenced by the BDNF polymorphism, with the greatest differences observed for the complex motor task. We also found unique motor cortex plasticity in the rarest form of the BDNF polymorphism (Met/Met subjects), which may have implications for functional recovery after disease or injury to the nervous system in these individuals.

AB - The purpose of this study was to investigate how healthy young subjects with one of three variants of the brain-derived neurotrophic factor (BDNF) gene modulate motor cortex excitability following experimentally induced and use-dependent plasticity interventions. Electromyographic recordings were obtained from the right first dorsal interosseous (FDI) muscle of 12Val/Val, ten Val/Met and seven Met/Met genotypes (aged 18-39years). Transcranial magnetic stimulation of the left hemisphere was used to assess changes in FDI motor-evoked potentials (MEPs) following three separate interventions involving paired associative stimulation, a simple ballistic task and complex visuomotor tracking task using the index finger. Val/Val subjects increased FDI MEPs following all interventions (≥25%, P<0.01), whereas the Met allele carriers only showed increased MEPs after the simple motor task (≥26%, P<0.01). In contrast to the simple motor task, there was no significant change in MEPs for the Val/Met subjects (7%, P=0.50) and a reduction in MEPs for the Met/Met group (-38%, P<0.01) following the complex motor task. Despite these differences in use-dependent plasticity, the performance of both motor tasks was not different between BDNF genotypes. We conclude that modulation of motor cortex excitability is strongly influenced by the BDNF polymorphism, with the greatest differences observed for the complex motor task. We also found unique motor cortex plasticity in the rarest form of the BDNF polymorphism (Met/Met subjects), which may have implications for functional recovery after disease or injury to the nervous system in these individuals.

KW - BDNF polymorphism

KW - Motor cortex

KW - Motor skill

KW - Transcranial magnetic stimulation

UR - http://www.scopus.com/inward/record.url?scp=84865866015&partnerID=8YFLogxK

U2 - 10.1111/j.1460-9568.2012.08177.x

DO - 10.1111/j.1460-9568.2012.08177.x

M3 - Article

VL - 36

SP - 2640

EP - 2649

JO - European Journal of Neuroscience

T2 - European Journal of Neuroscience

JF - European Journal of Neuroscience

SN - 0953-816X

IS - 5

ER -