Dietary lipid modulation of rat liver mitochondrial succinate: cytochrome c reductase

Edward J. McMurchie, Robert A. Gibson, Mahinda Y. Abeywardena, John S. Charnock

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Abstract

Diets supplemented with high levels of either saturated fatty acids or unsaturated fatty acids were fed to adult rats for a period of 9 weeks and changes in the liver mitochondrial membrane phospholipid fatty acid composition and thermal behaviour of succinate:cytochrome c reductase were determined. The dietary treatment induced a change in the ω6 to ω3 unsaturated fatty acid ratio in the membrane lipids, with the ratio being highest with the unsaturated fatty acid and lowest with the saturated fatty acid diet. Arrhenius plots of succinate:cytochrome c reductase activity exhibited differences in both critical temperature (Tr) and Arrhenius activation energy (Ea) depending on the type of dietary treatment. The Tf was elevated from 23°C in control to 32°C in the saturated fatty acid-supplemented group. No significant effect on the Tf was observed in the unsaturated fatty acid-supplemented group however higher Ea values were observed due to the unsaturated fatty acid diet. The changes in succinate:cytochrome c reductase are probably due to changes in the lipid-protein interactions in the membrane, induced by the dietary lipid supplementation.

Original languageEnglish
Pages (from-to)163-169
Number of pages7
JournalBBA - Biomembranes
Volume727
Issue number1
DOIs
Publication statusPublished - 5 Jan 1983
Externally publishedYes

Keywords

  • (Rat liver)
  • Lipid composition
  • Mitochondrial membrane
  • Succinate-cytochrome c reductase

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Medicine(all)

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