Dietary and ontogenic regulation of fatty acid desaturase and elongase expression in broiler chickens

M. Jing, N. Gakhar, R. A. Gibson, J. D. House

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Effects of diet and ontogeny on the expression of fatty acid desaturases and elongases were examined in broiler chickens. In Study 1, 120 day-old male chicks received one of six diets with LA:ALA ranging from 46:4 to 16:34, for 33 days. Total n-6 PUFA decreased, and n-3 PUFA increased in response to a decrease in the dietary LA:ALA. FADS1, FADS2, ELOVL2 and ELOVL5 mRNAs were highest (P<0.05) in birds fed lower LA:ALA diets. In Study 2, 60 day-old male chicks were fed a basal diet, and liver samples were collected on day of hatch, and on days 2, 7, 14, 21 and 35 post-hatch. Total n-6 and n-3 PUFA increased (P<0.01) from days 7 to days 21. FADS1, FADS2 and ELOVL2 mRNAs generally increased (P<0.01) with age. These findings provide evidence for the dietary and developmental regulation of PUFA metabolism in broiler chickens.

LanguageEnglish
Pages107-113
Number of pages7
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume89
Issue number2-3
DOIs
Publication statusPublished - 1 Aug 2013
Externally publishedYes

Keywords

  • Desaturation
  • Development
  • Diet
  • Elongation
  • Polyunsaturated fatty acids
  • Post-hatching

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

Cite this

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abstract = "Effects of diet and ontogeny on the expression of fatty acid desaturases and elongases were examined in broiler chickens. In Study 1, 120 day-old male chicks received one of six diets with LA:ALA ranging from 46:4 to 16:34, for 33 days. Total n-6 PUFA decreased, and n-3 PUFA increased in response to a decrease in the dietary LA:ALA. FADS1, FADS2, ELOVL2 and ELOVL5 mRNAs were highest (P<0.05) in birds fed lower LA:ALA diets. In Study 2, 60 day-old male chicks were fed a basal diet, and liver samples were collected on day of hatch, and on days 2, 7, 14, 21 and 35 post-hatch. Total n-6 and n-3 PUFA increased (P<0.01) from days 7 to days 21. FADS1, FADS2 and ELOVL2 mRNAs generally increased (P<0.01) with age. These findings provide evidence for the dietary and developmental regulation of PUFA metabolism in broiler chickens.",
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Dietary and ontogenic regulation of fatty acid desaturase and elongase expression in broiler chickens. / Jing, M.; Gakhar, N.; Gibson, R. A.; House, J. D.

In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 89, No. 2-3, 01.08.2013, p. 107-113.

Research output: Contribution to journalArticle

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