Diagnostic capability of colon capsule endoscopy for advanced colorectal cancer: A pilot study

Yumiko Ota, Atsuo Yamada, Yuka Kobayashi, Ryota Niikura, Takayuki Shimpoh, Akiko Narita, Shuntaro Yoshida, Nobumi Suzuki, Hirotsugu Watabe, Yoshihiro Hirata, Soichiro Ishihara, Eiji Sunami, Toshiaki Watanabe, Kazuhiko Koike

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Background and Aim: Colon capsule endoscopy (CCE) is a safe and effective method for detecting lesions in the colon. However, the sensitivity of CCE in detecting advanced colorectal cancer (CRC) has not been sufficiently evaluated. Therefore, the aim of the present study was to assess the sensitivity of CCE in detecting advanced CRC. Methods: Patients previously diagnosed with advanced CRC by conventional colonoscopy underwent CCE. Primary outcome measure was the sensitivity of CCE in detecting advanced CRC per patient and per lesion. Secondary parameters measured were the sensitivity of CCE in detecting polyps ≥6 mm and ≥10 mm in size in a per-lesion analysis and the safety of CCE. Results: Of the 21 advanced CRC lesions in 20 patients, 17 were detected by CCE. The per-patient and per-lesion sensitivities of CCE for detecting advanced CRC lesions were 85% (95% confidence interval [CI]: 62–97%) and 81% (95% CI: 58–95%), respectively. All advanced CRC lesions were diagnosed in the accessible region by CCE while the capsule was still functional. A significant association was found between incomplete CCE and failure to diagnose advanced CRC. No severe adverse events occurred. Conclusion: The diagnostic capability of CCE in detecting advanced CRC was limited in cases of procedure incompletion. Refining procedures to increase CCE procedure completion rates are required to enhance CRC detection.

Original languageEnglish
Pages (from-to)695-701
Number of pages7
JournalDigestive Endoscopy
Volume29
Issue number6
DOIs
Publication statusPublished or Issued - Sep 2017
Externally publishedYes

Keywords

  • capsule endoscopy
  • colonoscopy
  • colorectal cancer
  • diagnosis
  • sensitivity

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this