Design and Assessment of Anti-Biofilm Peptides: Steps Toward Clinical Application

Melanie Dostert, Corrie R. Belanger, Robert E.W. Hancock

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Highly antibiotic resistant, microbial communities, referred to as biofilms, cause various life-threatening infections in humans. At least two-thirds of all clinical infections are biofilm associated, and antibiotic therapy regularly fails to cure patients. Anti-biofilm peptides represent a promising approach to treat these infections by targeting biofilm-specific characteristics such as highly conserved regulatory mechanisms. They are being considered for clinical application and we discuss here key factors in discovery, design, and application, particularly the implementation of host-mimicking conditions, that are required to enable the successful advancement of potent anti-biofilm peptides from the bench to the clinic.

Original languageEnglish
Pages (from-to)193-204
Number of pages12
JournalJournal of Innate Immunity
Volume11
Issue number3
DOIs
Publication statusPublished - 1 Apr 2019
Externally publishedYes

Keywords

  • Anti-biofilm peptides
  • Biofilm infections
  • Physiologically relevant conditions

ASJC Scopus subject areas

  • Immunology and Allergy

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