Cytotoxicity of triorganophosphinegold(I) n-mercaptobenzoates, n = 2, 3 and 4

Dick De Vos, Douglas Smyth, Edward R.T. Tiekink

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The results of cytotoxicity trials against a panel of seven human cell lines for a series of triorganophosphinegold(I) 3- and 4-mercaptobenzoates are reported. While the new compounds show moderate to high toxicity, their potencies are inferior to those reported previously for their isomeric 2-mercaptobenzoate derivatives. The results therefore suggest a structure-activity relationship in that the 2-isomeric species are more active, particularly against the non-small cell lung cancer and renal cancer cell lines, results that may indicate some selectivity in their cytotoxic profile.

LanguageEnglish
Pages303-306
Number of pages4
JournalMetal-Based Drugs
Volume8
Issue number6
DOIs
Publication statusPublished - 1 Jan 2001
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Drug Discovery
  • Inorganic Chemistry

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