Cytotoxicity of triorganophosphinegold(I) complexes of thiobenzoate

Beverly R. Vincent, David J. Clarke, Douglas R. Smyth, Dick De Vos, Edward R.T. Tiekink

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The preparation and characterization of two triorganophosphinegold(I) complexes containing the anion derived from thiobenzoic acid are described. The cytotoxicity of these complexes has been investigated along with that of triphenylphosphinegold(I) mercaptopurinate, a known anti-tumor compound, against a variety of human cell lines. The complexes showed moderate to high cytotoxicity (ID50 250 - 2500 ng/ml).

Original languageEnglish
Pages (from-to)79-84
Number of pages6
JournalMetal-Based Drugs
Volume8
Issue number2
DOIs
Publication statusPublished - 1 Jan 2001

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology
  • Drug Discovery
  • Inorganic Chemistry

Cite this