Cytokines (IL-1β, IL-6, TNF-α, TGF-β1, and TGF-β2) and prostaglandin E2 in human milk during the first three months postpartum

Joanna S. Hawkes, Dani Louise Bryan, Michael J. James, Robert A. Gibson

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129 Citations (Scopus)

Abstract

Postpartum changes in the concentrations of IL-1β, IL-6, tumor necrosis factor-α (TNF-α), transforming growth factor-β1 (TGF-β1), TGF-β2, and prostaglandin E2 in 257 human milk samples collected longitudinally from 49 healthy mothers during the first 12 wk of lactation were determined by ELISA or RIA. The proinflammatory cytokines IL-1β, IL-6, and TNF-α were present in only a proportion of samples, and there was a wide range of concentrations detected at each time in the present study (IL-1β, <15-400 pg/mL; IL-6, <15- 1032 pg/mL; TNF-α, <15-2933 pg/mL). Concentrations of prostaglandin E2 increased after the first week and remained elevated for the remainder of the study (range, <10-9966 pg/mL). The antiinflammatory cytokines TGF-β1 (range, 43-7108 pg/mL) and TGF-β2 (range, 208-57935 pg/mL) were present in substantial quantities in all samples, and there was little change in the mean concentration during 12 wk of lactation. The present study shows that immunomodulating agents are normally present in human milk in physiologically relevant quantities for at least the first 3 mo of the breast-fed infant's life.

Original languageEnglish
Pages (from-to)194-199
Number of pages6
JournalPediatric Research
Volume46
Issue number2
DOIs
Publication statusPublished or Issued - Aug 1999

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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