Critical size bone defect healing using collagen-calcium phosphate bone graft materials

William Robert Walsh, Rema A. Oliver, Chris Christou, Vedran Lovric, Emma Rose Walsh, Gustavo R. Prado, Thomas Haider

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The need for bone graft materials to fill bony voids or gaps that are not related to the intrinsic stability of the bone that arise due to trauma, tumors or osteolysis remains a clinically relevant and significant issue. The in vivo response of collagentricalcium phosphate bone graft substitutes was evaluated in a critical size cancellous defect model in skeletally mature rabbits. While the materials were chemically virtually identical, new bone formation, implant resorption and local in vivo responses were significantly different. Differences in the in vivo response may be due, in part, collagen source and processing which influences resorption profiles. Continued improvements in processing and manufacturing techniques of collagen tricalcium phosphate bone graft substitutes can result in osteoconductive materials that support healing of critical size bone defects even in challenging pre-clinical models.

LanguageEnglish
Article numbere0168883
JournalPLoS ONE
Volume12
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Walsh, W. R., Oliver, R. A., Christou, C., Lovric, V., Walsh, E. R., Prado, G. R., & Haider, T. (2017). Critical size bone defect healing using collagen-calcium phosphate bone graft materials. PLoS ONE, 12(1), [e0168883]. https://doi.org/10.1371/journal.pone.0168883