Cost-effectiveness of single versus double embryo transfer in IVF in relation to female age

Laura L. van Loendersloot, Lobke M. Moolenaar, Madelon van wely, Sjoerd Repping, Patrick M. Bossuyt, Peter G.A. Hompes, Fulco van der Veen, Ben Willem J. Mol

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3 Citations (Scopus)

Abstract

Objective To evaluate the cost-effectiveness of single embryo transfer followed by an additional frozen-thawed single embryo transfer, if more embryos are available, as compared to double embryo transfer in relation to female age. Study design We used a decision tree model to evaluate the costs from a healthcare provider perspective and the pregnancy rates of two embryo transfer policies: one fresh single embryo transfer followed by an additional frozen-thawed single embryo transfer, if more embryos are available (strategy I), and double embryo transfer (strategy II). The analysis was performed on an intention-to-treat basis. Sensitivity analyses were carried out to evaluate the robustness of our model and to identify which model parameters had the strongest impact on the results. Results SET followed by an additional frozen-thawed single embryo transfer if available was dominant, less costly and more effective, over DET in women under 32 years. In women aged 32 or older DET was more effective than SET followed by an additional frozen-thawed single embryo transfer if available but also more costly. Conclusion SET followed by an additional frozen-thawed single embryo transfer should be the preferred strategy in women under 32 undergoing IVF. The choice for SET followed by an additional frozen-thawed single embryo transfer or DET in women aged 32 or older depends on individual patient preferences and on how much society is willing to pay for an extra child. There is a strong need for a randomized clinical trial comparing the cost and effects of SET followed by an additional frozen-thawed single embryo transfer and DET in the latter category of women.

LanguageEnglish
Pages25-30
Number of pages6
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume214
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • Costeffectiveness
  • Double embryo transfer
  • Female age
  • IVF
  • Singele embryo transfer

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

van Loendersloot, L. L., Moolenaar, L. M., van wely, M., Repping, S., Bossuyt, P. M., Hompes, P. G. A., ... Mol, B. W. J. (2017). Cost-effectiveness of single versus double embryo transfer in IVF in relation to female age. European Journal of Obstetrics and Gynecology and Reproductive Biology, 214, 25-30. https://doi.org/10.1016/j.ejogrb.2017.04.031