Cost-effectiveness of in vitro fertilization and embryo transfer

Ben W J Mol, Gouke J. Bonsel, John A. Collins, Maarten A H M Wiegerinck, Fulco Van Der Veen, Patrick M M Bossuyt

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Objective: Economic analyses in reproductive medicine often fail to take into account the chances of treatment-independent conception. We compared the cost-effectiveness of several realistic strategies involving IVF using no treatment as the reference strategy. Design: A decision tree was constructed for a subfertile couple in which the clinician had to decide whether to offer treatment with IVF. No treatment at all was used as the reference strategy.Setting: An analytic decision-making framework. Patient(s): Hypothetical subfertile couples. Intervention(s): Two potential treatment approaches: three IVF cycles performed as soon as possible, or no treatment performed initially and then three or four IVF cycles performed if a pregnancy resulting in a live birth does not occur naturally after 212 years. Main Outcome Measure(s): The cost of establishing one pregnancy that results in a live birth. Result(s): The cost-effectiveness of IVF depended not only on the costs and expected success rates of IVF itself but also on the couple-specific chances of treatment-independent conception. Consequently, the cost-effectiveness of IVF is strongly dependent on the age of the female partner. This finding corresponds with everyday clinical experience. Conclusion(s): Economic analyses in reproductive medicine should take into account the option of providing no treatment. Copyright (C) 2000 American Society for Reproductive Medicine.

Original languageEnglish
Pages (from-to)748-754
Number of pages7
JournalFertility and sterility
Volume73
Issue number4
DOIs
Publication statusPublished - 1 Apr 2000

Keywords

  • Cost-effectiveness
  • Economic analysis
  • IVF

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Mol, B. W. J., Bonsel, G. J., Collins, J. A., Wiegerinck, M. A. H. M., Van Der Veen, F., & Bossuyt, P. M. M. (2000). Cost-effectiveness of in vitro fertilization and embryo transfer. Fertility and sterility, 73(4), 748-754. https://doi.org/10.1016/S0015-0282(99)00610-X