Controversies on HDL: Should it be a target biomarker in patients with lipid disorders?

Stephen J. Nicholls, Jordan Andrews, Ngan MyDuong

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Low-density lipoprotein (LDL) cholesterol lowering with statins have had a profound impact on cardiovascular (CV) event rates and accordingly have become an integral component of strategies designed to reduce CV risk. The finding of a residual clinical risk, despite LDL cholesterol lowering, supports the need to develop additional therapeutic strategies for CV prevention. Numerous lines of evidence suggest that targeting the protective properties of high-density lipoproteins (HDL) may be beneficial. Disappointing results from recent reports of HDL genetics and raising agents and clinical events has fueled considerable debate as to whether attempts to target HDL will be of clinical benefit or futility. This review will reflect on challenges faced in developing new effective HDL targeted therapies.

Original languageEnglish
Pages (from-to)649-652
Number of pages4
JournalCurrent Vascular Pharmacology
Issue number4
Publication statusPublished or Issued - 2014


  • Atherosclerosis
  • High-density lipoproteins
  • Lipids
  • Risk factors

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine

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