Concise review: Preclinical studies on human cell-based therapy in rodent ischemic stroke models: Where are we now after a decade?

Research output: Contribution to journalShort surveypeer-review

26 Citations (Scopus)

Abstract

Stroke, a debilitating brain insult, afflicts millions of individuals globally each year. In the last decade, researchers have investigated cell-based therapy as an alternative strategy to improve neurological outcome following stroke. This concise review critically examines preclinical reports using human adult and fetal stem/progenitor cells in rodent models of ischemic stroke. As we enter the second decade of study, we should aim to optimize our collective likelihood to translational success for stroke victims worldwide. We advocate international consensus recommendations be developed for future preclinical research.

Original languageEnglish
Pages (from-to)1040-1043
Number of pages4
JournalStem Cells
Volume31
Issue number6
DOIs
Publication statusPublished or Issued - 1 Jun 2013

Keywords

  • Cell-based therapy
  • Human stem/progenitor cells
  • Ischemic stroke
  • Middle cerebral artery occlusion
  • Rat model

ASJC Scopus subject areas

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

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