Computationally estimated apolipoproteins B and A1 in predicting cardiovascular risk

Olli T. Raitakari, Ville Petteri Mäkinen, Matthew J. McQueen, Jaakko Niemi, Markus Juonala, Matti Jauhiainen, Veikko Salomaa, Minna L. Hannuksela, Markku J. Savolainen, Y. Antero Kesäniemi, Petri T. Kovanen, Jouko Sundvall, Tiina Solakivi, Britt Marie Loo, Jukka Marniemi, Jussi Hernesniemi, Terho Lehtimäki, Mika Kähönen, Markku Peltonen, Jaana LeiviskäAntti Jula, Sonia S. Anand, Ruby Miller, Salim Yusuf, Jorma S.A. Viikari, Mika Ala-Korpela

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Objective: Apolipoproteins B (apoB) and A1 (apoA1) may be better markers of atherosclerosis than serum lipids. We used computational methods to estimate apoB and apoA1 from serum total cholesterol, HDL-cholesterol and triglycerides and tested their clinical value in comparison to measured apoB and apoA1 values. Methods: ApoB and apoA1 were measured with standard methods and estimated based on neural network regression models in 2166 young adult with data on carotid artery intima-media thickness (cIMT). Results: Correlations between estimated and measured apoB and apoA1 were r = 0.98 and r = 0.95, respectively. ApoB/apoA1-ratio (both measured and estimated) associated with cIMT in multivariable models, and predicted cIMT at all levels of LDL-cholesterol concentration. Strong correlations between the estimated apolipoproteins and those measured from fasting samples were replicated in over 15,000 Caucasian subjects (r = 0.93-0.96 for apoB and r = 0.91-0.92 for apoA1). Correlations with cIMT were replicated in over 2000 individuals. Estimated apoB/apoA1-ratio calculated from non-fasting lipids in over 20,000 individuals in the INTERHEART study was better than any of the cholesterol measures for estimation of the myocardial risk. Conclusions: Serum cholesterol, HDL-cholesterol and triglycerides can be used to compute clinically useful estimates of apoB and apoA1. Using this methodology, estimates of apolipoproteins could be routinely added to laboratory reports to complement lipoprotein lipids in risk assessment.

Original languageEnglish
Pages (from-to)245-251
Number of pages7
JournalAtherosclerosis
Volume226
Issue number1
DOIs
Publication statusPublished - Jan 2013

Keywords

  • Apolipoproteins
  • Atherosclerosis
  • Carotid ultrasound
  • Computational methods
  • Neural networks

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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