Abstract
Background: Following preoperative treatment of rectal cancer with chemoradiotherapy (CRT), a complete pathological response (CPR) can be seen in the surgical specimen. The aim of this study was to assess the outcome of these patients as compared with those who did not have a complete response. Methods: A retrospective study of the outcome of patients managed with preoperative CRT for their rectal cancer was conducted. Results: Between November 1998 and July 2004, there were 530 new presentations of rectal cancer at The Queen Elizabeth and Royal Adelaide hospitals. Forty of these patients (7.5%) were treated with long-course preoperative CRT. After resection, a CPR was seen in seven patients (17.5%). These patients were all disease free at January 2006 after a median follow-up of 6.0 years (range 1.42-7.02 years). One patient had died from non-tumour-/surgery-related causes. Tumour recurrence, but not mortality, in this group was superior to the comparison group of patients without a CPR. Conclusions: None of our patients who had a CPR after preoperative CRT have recurred or died from their disease.
| Language | English |
|---|---|
| Pages | 481-484 |
| Number of pages | 4 |
| Journal | ANZ Journal of Surgery |
| Volume | 79 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1 Jun 2009 |
| Externally published | Yes |
Keywords
- Adjuvant chemotherapy
- Adjuvant radiotherapy
- Rectal neoplasm
- Recurrence
- Survival rate
ASJC Scopus subject areas
- Surgery
Cite this
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Complete pathologic response after preoperative rectal cancer chemoradiotherapy. / Ciccocioppo, Anthony; Stephens, Jacqueline; Hewett, Peter J.; Rieger, Nicholas A.
In: ANZ Journal of Surgery, Vol. 79, No. 6, 01.06.2009, p. 481-484.Research output: Contribution to journal › Article
TY - JOUR
T1 - Complete pathologic response after preoperative rectal cancer chemoradiotherapy
AU - Ciccocioppo, Anthony
AU - Stephens, Jacqueline
AU - Hewett, Peter J.
AU - Rieger, Nicholas A.
PY - 2009/6/1
Y1 - 2009/6/1
N2 - Background: Following preoperative treatment of rectal cancer with chemoradiotherapy (CRT), a complete pathological response (CPR) can be seen in the surgical specimen. The aim of this study was to assess the outcome of these patients as compared with those who did not have a complete response. Methods: A retrospective study of the outcome of patients managed with preoperative CRT for their rectal cancer was conducted. Results: Between November 1998 and July 2004, there were 530 new presentations of rectal cancer at The Queen Elizabeth and Royal Adelaide hospitals. Forty of these patients (7.5%) were treated with long-course preoperative CRT. After resection, a CPR was seen in seven patients (17.5%). These patients were all disease free at January 2006 after a median follow-up of 6.0 years (range 1.42-7.02 years). One patient had died from non-tumour-/surgery-related causes. Tumour recurrence, but not mortality, in this group was superior to the comparison group of patients without a CPR. Conclusions: None of our patients who had a CPR after preoperative CRT have recurred or died from their disease.
AB - Background: Following preoperative treatment of rectal cancer with chemoradiotherapy (CRT), a complete pathological response (CPR) can be seen in the surgical specimen. The aim of this study was to assess the outcome of these patients as compared with those who did not have a complete response. Methods: A retrospective study of the outcome of patients managed with preoperative CRT for their rectal cancer was conducted. Results: Between November 1998 and July 2004, there were 530 new presentations of rectal cancer at The Queen Elizabeth and Royal Adelaide hospitals. Forty of these patients (7.5%) were treated with long-course preoperative CRT. After resection, a CPR was seen in seven patients (17.5%). These patients were all disease free at January 2006 after a median follow-up of 6.0 years (range 1.42-7.02 years). One patient had died from non-tumour-/surgery-related causes. Tumour recurrence, but not mortality, in this group was superior to the comparison group of patients without a CPR. Conclusions: None of our patients who had a CPR after preoperative CRT have recurred or died from their disease.
KW - Adjuvant chemotherapy
KW - Adjuvant radiotherapy
KW - Rectal neoplasm
KW - Recurrence
KW - Survival rate
UR - http://www.scopus.com/inward/record.url?scp=67650613918&partnerID=8YFLogxK
U2 - 10.1111/j.1445-2197.2009.04950.x
DO - 10.1111/j.1445-2197.2009.04950.x
M3 - Article
VL - 79
SP - 481
EP - 484
JO - ANZ Journal of Surgery
T2 - ANZ Journal of Surgery
JF - ANZ Journal of Surgery
SN - 1445-1433
IS - 6
ER -