Comparison of trough, 2-hour, and limited AUC blood sampling for monitoring cyclosporin (Neoral®) at day 7 post-renal transplantation and incidence of rejection in the first month

Raymond G. Morris, Graeme R. Russ, Matthew J. Cervelli, Rajiv Juneja, Stephen McDonald, Timothy H. Mathew

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

The use of alternative strategies to the traditional pre-dose/trough (C0) blood sampling for cyclosporine (CsA) therapeutic drug monitoring has the potential to revolutionize analytical practices which have, in many centers, been established for some 20 years. While the C0 sample has previously been recommended, current attitudes are increasingly proposing alternatives for assessing CsA exposure, including various limited sampling strategies of the AUC (lssAUC) in the early postdose period, or alternative single-point nontrough samples, such as a 2-hour postdose sample (C2). The present study has reviewed a series of consecutive renal transplant recipients over 18 months where CsA was the primary immunosuppressant. The lssAUC performed at around day 7 posttransplantation included drawing blood at 0, 2, and 4 hours postdose, giving AUC(0-4). The aim of this study was to review the occurrence of acute biopsy-proven rejection in the first month and consider which of (simultaneously measured) C0, C2 or AUC(0-4) was a better early indicator of this adverse outcome. The result was best described by comparing the data from rejectors (n = 13) and nonrejectors (n= 42) for these 3 indices of CsA exposure (i.e., C0, C2 or AUC(0-4). There was no evidence that CO predicted the likelihood of such adverse clinical outcomes. In contrast, rejectors tended to have lower mean C2 CsA concentrations, and the incidence of rejection was 0.0 when C2 exceeded 1200 μg/L (n = 10). While the data are limited in the higher C2 CsA concentration range, it is nevertheless consistent with more recent recommendations suggesting that the CsA at C2 should target 1700 μg/L in this first month posttransplantation. As 64% of the patients were also receiving a CsA-sparing agent (diltiazem [DTZ]), the relationships were also investigated to determine whether any affect of concomitant DTZ therapy could be demonstrated. However, in this small sample, no significant affect of DTZ was seen.

LanguageEnglish
Pages479-486
Number of pages8
JournalTherapeutic Drug Monitoring
Volume24
Issue number4
DOIs
Publication statusPublished - 19 Aug 2002
Externally publishedYes

Keywords

  • Cyclosporine
  • Therapeutic drug monitoring
  • Transplantation

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

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title = "Comparison of trough, 2-hour, and limited AUC blood sampling for monitoring cyclosporin (Neoral{\circledR}) at day 7 post-renal transplantation and incidence of rejection in the first month",
abstract = "The use of alternative strategies to the traditional pre-dose/trough (C0) blood sampling for cyclosporine (CsA) therapeutic drug monitoring has the potential to revolutionize analytical practices which have, in many centers, been established for some 20 years. While the C0 sample has previously been recommended, current attitudes are increasingly proposing alternatives for assessing CsA exposure, including various limited sampling strategies of the AUC (lssAUC) in the early postdose period, or alternative single-point nontrough samples, such as a 2-hour postdose sample (C2). The present study has reviewed a series of consecutive renal transplant recipients over 18 months where CsA was the primary immunosuppressant. The lssAUC performed at around day 7 posttransplantation included drawing blood at 0, 2, and 4 hours postdose, giving AUC(0-4). The aim of this study was to review the occurrence of acute biopsy-proven rejection in the first month and consider which of (simultaneously measured) C0, C2 or AUC(0-4) was a better early indicator of this adverse outcome. The result was best described by comparing the data from rejectors (n = 13) and nonrejectors (n= 42) for these 3 indices of CsA exposure (i.e., C0, C2 or AUC(0-4). There was no evidence that CO predicted the likelihood of such adverse clinical outcomes. In contrast, rejectors tended to have lower mean C2 CsA concentrations, and the incidence of rejection was 0.0 when C2 exceeded 1200 μg/L (n = 10). While the data are limited in the higher C2 CsA concentration range, it is nevertheless consistent with more recent recommendations suggesting that the CsA at C2 should target 1700 μg/L in this first month posttransplantation. As 64{\%} of the patients were also receiving a CsA-sparing agent (diltiazem [DTZ]), the relationships were also investigated to determine whether any affect of concomitant DTZ therapy could be demonstrated. However, in this small sample, no significant affect of DTZ was seen.",
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Comparison of trough, 2-hour, and limited AUC blood sampling for monitoring cyclosporin (Neoral®) at day 7 post-renal transplantation and incidence of rejection in the first month. / Morris, Raymond G.; Russ, Graeme R.; Cervelli, Matthew J.; Juneja, Rajiv; McDonald, Stephen; Mathew, Timothy H.

In: Therapeutic Drug Monitoring, Vol. 24, No. 4, 19.08.2002, p. 479-486.

Research output: Contribution to journalArticle

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T1 - Comparison of trough, 2-hour, and limited AUC blood sampling for monitoring cyclosporin (Neoral®) at day 7 post-renal transplantation and incidence of rejection in the first month

AU - Morris, Raymond G.

AU - Russ, Graeme R.

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AU - Mathew, Timothy H.

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AB - The use of alternative strategies to the traditional pre-dose/trough (C0) blood sampling for cyclosporine (CsA) therapeutic drug monitoring has the potential to revolutionize analytical practices which have, in many centers, been established for some 20 years. While the C0 sample has previously been recommended, current attitudes are increasingly proposing alternatives for assessing CsA exposure, including various limited sampling strategies of the AUC (lssAUC) in the early postdose period, or alternative single-point nontrough samples, such as a 2-hour postdose sample (C2). The present study has reviewed a series of consecutive renal transplant recipients over 18 months where CsA was the primary immunosuppressant. The lssAUC performed at around day 7 posttransplantation included drawing blood at 0, 2, and 4 hours postdose, giving AUC(0-4). The aim of this study was to review the occurrence of acute biopsy-proven rejection in the first month and consider which of (simultaneously measured) C0, C2 or AUC(0-4) was a better early indicator of this adverse outcome. The result was best described by comparing the data from rejectors (n = 13) and nonrejectors (n= 42) for these 3 indices of CsA exposure (i.e., C0, C2 or AUC(0-4). There was no evidence that CO predicted the likelihood of such adverse clinical outcomes. In contrast, rejectors tended to have lower mean C2 CsA concentrations, and the incidence of rejection was 0.0 when C2 exceeded 1200 μg/L (n = 10). While the data are limited in the higher C2 CsA concentration range, it is nevertheless consistent with more recent recommendations suggesting that the CsA at C2 should target 1700 μg/L in this first month posttransplantation. As 64% of the patients were also receiving a CsA-sparing agent (diltiazem [DTZ]), the relationships were also investigated to determine whether any affect of concomitant DTZ therapy could be demonstrated. However, in this small sample, no significant affect of DTZ was seen.

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