Combining whispering gallery mode lasers and microstructured optical fibers for in-vivo biosensing applications

A. Francois, K. J. Rowland, T. Reynolds, S. J. Nicholls, T. M. Monro

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

Whispering Gallery Modes (WGMs) have been widely studied for the past 20 years for various applications, including biological sensing. While the different WGM-based sensing approaches reported in the literature enable useful sensor characteristics, at present this technology is not yet mature, mainly for practical reasons. Our work has been focused on developing a simple, yet efficient, WGM-based sensing platform capable of being used as a dip sensor for in-vivo biosensing applications. We recently demonstrated that a dye-doped polymer microresonator, supporting WGMs, positioned onto the tip of a suspended core Microstructured Optical Fiber can be used as a dip sensor. In this architecture, the resonator is located on an air hole next to the fiber core at the fiber's tip, enabling a significant portion of the sphere to overlap with the guided light emerging from the fiber tip. This architecture offers significant benefits that have never been reported in the literature in terms of radiation efficiency, compared to the standard freestanding resonators, which arise from breaking the symmetry of the resonator. In addition to providing the remote excitation and collection of the WGMs' signal, the fiber also allows easy manipulation of the microresonator and the use this sensor in a dip sensing architecture, alleviating the need for a complex microfluidic interface. Here, we present our recent results on the microstructured fiber tip WGM-based sensor, including its lasing behavior and enhancement of the radiation efficiency as a function of the position of the resonator on the fiber tip. We also show that this platform can be used for clinical diagnostics and applying this technology to the detection of Troponin T, an acute myocardial infarction biomarker, down to a concentration of 7.4 pg/mL.

LanguageEnglish
Title of host publicationPhotonics North 2013
Volume8915
DOIs
Publication statusPublished - 2013
EventPhotonics North 2013 Conference - Ottawa, ON, Canada
Duration: 3 Jun 20135 Jun 2013

Other

OtherPhotonics North 2013 Conference
CountryCanada
CityOttawa, ON
Period3/06/135/06/13

Keywords

  • Biosensors
  • Microstructured Optical Fiber
  • Whispering Gallery Mode

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Francois, A., Rowland, K. J., Reynolds, T., Nicholls, S. J., & Monro, T. M. (2013). Combining whispering gallery mode lasers and microstructured optical fibers for in-vivo biosensing applications. In Photonics North 2013 (Vol. 8915). [891518] https://doi.org/10.1117/12.2037511
Francois, A. ; Rowland, K. J. ; Reynolds, T. ; Nicholls, S. J. ; Monro, T. M. / Combining whispering gallery mode lasers and microstructured optical fibers for in-vivo biosensing applications. Photonics North 2013. Vol. 8915 2013.
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Francois, A, Rowland, KJ, Reynolds, T, Nicholls, SJ & Monro, TM 2013, Combining whispering gallery mode lasers and microstructured optical fibers for in-vivo biosensing applications. in Photonics North 2013. vol. 8915, 891518, Photonics North 2013 Conference, Ottawa, ON, Canada, 3/06/13. https://doi.org/10.1117/12.2037511

Combining whispering gallery mode lasers and microstructured optical fibers for in-vivo biosensing applications. / Francois, A.; Rowland, K. J.; Reynolds, T.; Nicholls, S. J.; Monro, T. M.

Photonics North 2013. Vol. 8915 2013. 891518.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AU - Nicholls, S. J.

AU - Monro, T. M.

PY - 2013

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N2 - Whispering Gallery Modes (WGMs) have been widely studied for the past 20 years for various applications, including biological sensing. While the different WGM-based sensing approaches reported in the literature enable useful sensor characteristics, at present this technology is not yet mature, mainly for practical reasons. Our work has been focused on developing a simple, yet efficient, WGM-based sensing platform capable of being used as a dip sensor for in-vivo biosensing applications. We recently demonstrated that a dye-doped polymer microresonator, supporting WGMs, positioned onto the tip of a suspended core Microstructured Optical Fiber can be used as a dip sensor. In this architecture, the resonator is located on an air hole next to the fiber core at the fiber's tip, enabling a significant portion of the sphere to overlap with the guided light emerging from the fiber tip. This architecture offers significant benefits that have never been reported in the literature in terms of radiation efficiency, compared to the standard freestanding resonators, which arise from breaking the symmetry of the resonator. In addition to providing the remote excitation and collection of the WGMs' signal, the fiber also allows easy manipulation of the microresonator and the use this sensor in a dip sensing architecture, alleviating the need for a complex microfluidic interface. Here, we present our recent results on the microstructured fiber tip WGM-based sensor, including its lasing behavior and enhancement of the radiation efficiency as a function of the position of the resonator on the fiber tip. We also show that this platform can be used for clinical diagnostics and applying this technology to the detection of Troponin T, an acute myocardial infarction biomarker, down to a concentration of 7.4 pg/mL.

AB - Whispering Gallery Modes (WGMs) have been widely studied for the past 20 years for various applications, including biological sensing. While the different WGM-based sensing approaches reported in the literature enable useful sensor characteristics, at present this technology is not yet mature, mainly for practical reasons. Our work has been focused on developing a simple, yet efficient, WGM-based sensing platform capable of being used as a dip sensor for in-vivo biosensing applications. We recently demonstrated that a dye-doped polymer microresonator, supporting WGMs, positioned onto the tip of a suspended core Microstructured Optical Fiber can be used as a dip sensor. In this architecture, the resonator is located on an air hole next to the fiber core at the fiber's tip, enabling a significant portion of the sphere to overlap with the guided light emerging from the fiber tip. This architecture offers significant benefits that have never been reported in the literature in terms of radiation efficiency, compared to the standard freestanding resonators, which arise from breaking the symmetry of the resonator. In addition to providing the remote excitation and collection of the WGMs' signal, the fiber also allows easy manipulation of the microresonator and the use this sensor in a dip sensing architecture, alleviating the need for a complex microfluidic interface. Here, we present our recent results on the microstructured fiber tip WGM-based sensor, including its lasing behavior and enhancement of the radiation efficiency as a function of the position of the resonator on the fiber tip. We also show that this platform can be used for clinical diagnostics and applying this technology to the detection of Troponin T, an acute myocardial infarction biomarker, down to a concentration of 7.4 pg/mL.

KW - Biosensors

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DO - 10.1117/12.2037511

M3 - Conference contribution

SN - 9780819497918

VL - 8915

BT - Photonics North 2013

ER -

Francois A, Rowland KJ, Reynolds T, Nicholls SJ, Monro TM. Combining whispering gallery mode lasers and microstructured optical fibers for in-vivo biosensing applications. In Photonics North 2013. Vol. 8915. 2013. 891518 https://doi.org/10.1117/12.2037511