Colorectal carcinogenesis: Road maps to cancer

Daniel L. Worthley, Vicki L. Whitehall, Kevin J. Spring, Barbara A. Leggett

Research output: Contribution to journalReview article

95 Citations (Scopus)


This review explores the chief genetic and epigenetic events that promote pathological progression in colorectal carcinogenesis. This article discusses the molecular and pathological basis for classifying colorectal neoplasia into suppressor, mutator and methylator pathways. These differing mechanisms of genomic instability are associated with specific cancer characteristics, and may provide the opportunity for more effective prevention and surveillance strategies in the future. This is the first review in a series of five topics outlining important and developing aspects of colorectal cancer.

Original languageEnglish
Pages (from-to)3784-3791
Number of pages8
JournalWorld Journal of Gastroenterology
Issue number28
Publication statusPublished - 28 Jul 2007


  • Adenoma-carcinoma sequence
  • Adenomas
  • Colorectal cancer
  • CpG Island methylator phenotype
  • Hyperplastic polyps, Microsatellite instability
  • Neoplastic processes
  • Serrated adenoma

ASJC Scopus subject areas

  • Gastroenterology

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