Cognition in schizophrenia improves with treatment of severe obstructive sleep apnoea: A pilot study

Hannah Myles, Nicholas Myles, Ching Li Chai Coetzer, Robert Adams, Madhu Chandratilleke, Dennis Liu, Jeremy Mercer, Andrew Vakulin, Andrew Vincent, Gary Wittert, Cherrie Galletly

Research output: Research - peer-reviewArticle

Abstract

Previous studies have shown that people with schizophrenia have high rates of Obstructive Sleep Apnoea (OSA). Despite this, intervention studies to treat OSA in this population have not been undertaken. The ASSET (Assessing Sleep in Schizophrenia and Evaluating Treatment) pilot study investigated Continuous Positive Airway Pressure (CPAP) treatment of severe OSA in participants recruited from a clozapine clinic in Adelaide. Participants with severe untreated OSA (Apnoea-Hypopnoea Index (AHI) > 30), were provided with CPAP treatment, and assessed at baseline and six months across the following domains: physical health, quality of sleep, sleepiness, cognition, psychiatric symptoms and CPAP adherence. Six of the eight ASSET participants with severe OSA accepted CPAP. At baseline, half of the cohort had hypertension, all were obese with a mean BMI of 45, and they scored on average 1.47 standard deviations below the normal population in cognitive testing. The mean AHI was 76.8 and sleep architecture was markedly impaired with mean rapid eye movement (REM) sleep 4.1% and mean slow wave sleep (SWS) 4.8%. After six months of treatment there were improvements in cognition (BACS Z score improved by an average of 0.59) and weight loss (mean weight loss 7.3 ± 9 kg). Half of the participants no longer had hypertension and sleep architecture improved with mean REM sleep 31.4% of the night and mean SWS 24% of the night. Our data suggests CPAP may offer novel benefits to address cognitive impairment and sleep disturbance in people with schizophrenia.

LanguageEnglish
Pages14-20
Number of pages7
JournalSchizophrenia Research: Cognition
Volume15
DOIs
StatePublished - 1 Mar 2019

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Psychiatry and Mental health

Cite this

Myles, H., Myles, N., Coetzer, C. L. C., Adams, R., Chandratilleke, M., Liu, D., ... Galletly, C. (2019). Cognition in schizophrenia improves with treatment of severe obstructive sleep apnoea: A pilot study. Schizophrenia Research: Cognition, 15, 14-20. DOI: 10.1016/j.scog.2018.09.001
Myles, Hannah ; Myles, Nicholas ; Coetzer, Ching Li Chai ; Adams, Robert ; Chandratilleke, Madhu ; Liu, Dennis ; Mercer, Jeremy ; Vakulin, Andrew ; Vincent, Andrew ; Wittert, Gary ; Galletly, Cherrie. / Cognition in schizophrenia improves with treatment of severe obstructive sleep apnoea : A pilot study. In: Schizophrenia Research: Cognition. 2019 ; Vol. 15. pp. 14-20
@article{92af953b847f4d81bbb38650e25ac207,
title = "Cognition in schizophrenia improves with treatment of severe obstructive sleep apnoea: A pilot study",
abstract = "Previous studies have shown that people with schizophrenia have high rates of Obstructive Sleep Apnoea (OSA). Despite this, intervention studies to treat OSA in this population have not been undertaken. The ASSET (Assessing Sleep in Schizophrenia and Evaluating Treatment) pilot study investigated Continuous Positive Airway Pressure (CPAP) treatment of severe OSA in participants recruited from a clozapine clinic in Adelaide. Participants with severe untreated OSA (Apnoea-Hypopnoea Index (AHI) > 30), were provided with CPAP treatment, and assessed at baseline and six months across the following domains: physical health, quality of sleep, sleepiness, cognition, psychiatric symptoms and CPAP adherence. Six of the eight ASSET participants with severe OSA accepted CPAP. At baseline, half of the cohort had hypertension, all were obese with a mean BMI of 45, and they scored on average 1.47 standard deviations below the normal population in cognitive testing. The mean AHI was 76.8 and sleep architecture was markedly impaired with mean rapid eye movement (REM) sleep 4.1% and mean slow wave sleep (SWS) 4.8%. After six months of treatment there were improvements in cognition (BACS Z score improved by an average of 0.59) and weight loss (mean weight loss 7.3 ± 9 kg). Half of the participants no longer had hypertension and sleep architecture improved with mean REM sleep 31.4% of the night and mean SWS 24% of the night. Our data suggests CPAP may offer novel benefits to address cognitive impairment and sleep disturbance in people with schizophrenia.",
author = "Hannah Myles and Nicholas Myles and Coetzer, {Ching Li Chai} and Robert Adams and Madhu Chandratilleke and Dennis Liu and Jeremy Mercer and Andrew Vakulin and Andrew Vincent and Gary Wittert and Cherrie Galletly",
year = "2019",
month = "3",
doi = "10.1016/j.scog.2018.09.001",
volume = "15",
pages = "14--20",
journal = "Schizophrenia Research: Cognition",
issn = "2215-0013",

}

Myles, H, Myles, N, Coetzer, CLC, Adams, R, Chandratilleke, M, Liu, D, Mercer, J, Vakulin, A, Vincent, A, Wittert, G & Galletly, C 2019, 'Cognition in schizophrenia improves with treatment of severe obstructive sleep apnoea: A pilot study' Schizophrenia Research: Cognition, vol 15, pp. 14-20. DOI: 10.1016/j.scog.2018.09.001

Cognition in schizophrenia improves with treatment of severe obstructive sleep apnoea : A pilot study. / Myles, Hannah; Myles, Nicholas; Coetzer, Ching Li Chai; Adams, Robert; Chandratilleke, Madhu; Liu, Dennis; Mercer, Jeremy; Vakulin, Andrew; Vincent, Andrew; Wittert, Gary; Galletly, Cherrie.

In: Schizophrenia Research: Cognition, Vol. 15, 01.03.2019, p. 14-20.

Research output: Research - peer-reviewArticle

TY - JOUR

T1 - Cognition in schizophrenia improves with treatment of severe obstructive sleep apnoea

T2 - Schizophrenia Research: Cognition

AU - Myles,Hannah

AU - Myles,Nicholas

AU - Coetzer,Ching Li Chai

AU - Adams,Robert

AU - Chandratilleke,Madhu

AU - Liu,Dennis

AU - Mercer,Jeremy

AU - Vakulin,Andrew

AU - Vincent,Andrew

AU - Wittert,Gary

AU - Galletly,Cherrie

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Previous studies have shown that people with schizophrenia have high rates of Obstructive Sleep Apnoea (OSA). Despite this, intervention studies to treat OSA in this population have not been undertaken. The ASSET (Assessing Sleep in Schizophrenia and Evaluating Treatment) pilot study investigated Continuous Positive Airway Pressure (CPAP) treatment of severe OSA in participants recruited from a clozapine clinic in Adelaide. Participants with severe untreated OSA (Apnoea-Hypopnoea Index (AHI) > 30), were provided with CPAP treatment, and assessed at baseline and six months across the following domains: physical health, quality of sleep, sleepiness, cognition, psychiatric symptoms and CPAP adherence. Six of the eight ASSET participants with severe OSA accepted CPAP. At baseline, half of the cohort had hypertension, all were obese with a mean BMI of 45, and they scored on average 1.47 standard deviations below the normal population in cognitive testing. The mean AHI was 76.8 and sleep architecture was markedly impaired with mean rapid eye movement (REM) sleep 4.1% and mean slow wave sleep (SWS) 4.8%. After six months of treatment there were improvements in cognition (BACS Z score improved by an average of 0.59) and weight loss (mean weight loss 7.3 ± 9 kg). Half of the participants no longer had hypertension and sleep architecture improved with mean REM sleep 31.4% of the night and mean SWS 24% of the night. Our data suggests CPAP may offer novel benefits to address cognitive impairment and sleep disturbance in people with schizophrenia.

AB - Previous studies have shown that people with schizophrenia have high rates of Obstructive Sleep Apnoea (OSA). Despite this, intervention studies to treat OSA in this population have not been undertaken. The ASSET (Assessing Sleep in Schizophrenia and Evaluating Treatment) pilot study investigated Continuous Positive Airway Pressure (CPAP) treatment of severe OSA in participants recruited from a clozapine clinic in Adelaide. Participants with severe untreated OSA (Apnoea-Hypopnoea Index (AHI) > 30), were provided with CPAP treatment, and assessed at baseline and six months across the following domains: physical health, quality of sleep, sleepiness, cognition, psychiatric symptoms and CPAP adherence. Six of the eight ASSET participants with severe OSA accepted CPAP. At baseline, half of the cohort had hypertension, all were obese with a mean BMI of 45, and they scored on average 1.47 standard deviations below the normal population in cognitive testing. The mean AHI was 76.8 and sleep architecture was markedly impaired with mean rapid eye movement (REM) sleep 4.1% and mean slow wave sleep (SWS) 4.8%. After six months of treatment there were improvements in cognition (BACS Z score improved by an average of 0.59) and weight loss (mean weight loss 7.3 ± 9 kg). Half of the participants no longer had hypertension and sleep architecture improved with mean REM sleep 31.4% of the night and mean SWS 24% of the night. Our data suggests CPAP may offer novel benefits to address cognitive impairment and sleep disturbance in people with schizophrenia.

UR - http://www.scopus.com/inward/record.url?scp=85056175454&partnerID=8YFLogxK

U2 - 10.1016/j.scog.2018.09.001

DO - 10.1016/j.scog.2018.09.001

M3 - Article

VL - 15

SP - 14

EP - 20

JO - Schizophrenia Research: Cognition

JF - Schizophrenia Research: Cognition

SN - 2215-0013

ER -

Myles H, Myles N, Coetzer CLC, Adams R, Chandratilleke M, Liu D et al. Cognition in schizophrenia improves with treatment of severe obstructive sleep apnoea: A pilot study. Schizophrenia Research: Cognition. 2019 Mar 1;15:14-20. Available from, DOI: 10.1016/j.scog.2018.09.001