Clinical predictors of noninducibility of sustained atrial fibrillation after pulmonary vein isolation

Martin Rotter, Pierre Jaïs, Stephane Garrigue, Prashanthan Sanders, Mélèze Hocini, Li Fern Hsu, Yoshihide Takahashi, Thomas Rostock, Fréderic Sacher, Jacques Clementy, Michel Haïssaguerre

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18 Citations (Scopus)

Abstract

Predictors of Noninducibility of AF. Background: Noninducibility of sustained atrial fibrillation (AF) after pulmonary vein isolation (PVI) has been shown to be associated with a better clinical outcome. We evaluated the role of clinical variables that could predict noninducibility of sustained AF after PVI. Methods and Results: Data were collected prospectively from 181 patients (153 male; age 54 ± 9 years) referred for ablation of drug-refractory symptomatic paroxysmal AF (duration ≤7 days). Clinical variables were evaluated with regard to their ability of predicting noninducibility of sustained AF (≤10 minutes) after PVI. Univariate analysis was performed on all collected variables followed by multivariate analysis for variables showing a P value <0.1. After PVI, sustained AF was noninducible in 97 (54%) patients. The following clinical variables showed a significant difference between the groups: body weight, longest AF episode, duration of AF history, presence or absence of structural heart disease, left ventricular (LV) hypertrophy, prior cardioversion, left atrial (LA) parasternal, and longitudinal diameters and LV diameters. On multivariate analysis, three independent predictors of noninducibility were identified: a shorter duration of AF episodes (AF <12 hours: RR 0.01 (0.002-0.06), P < 0.001; AF 12-48 hours: RR 0.07 (0.01-0.37), P = 0.001); LA longitudinal diameter <57 mm (RR 0.33 (0.13-0.82), P = 0.016); and absence of LV hypertrophy (RR 0.15 (0.04-0.63), P = 0.01). Conclusions: Shorter AF episodes, smaller LA longitudinal diameter, and absence of LV hypertrophy are independent predictors of noninducibility of sustained AF after PVI.

Original languageEnglish
Pages (from-to)1298-1303
Number of pages6
JournalJournal of Cardiovascular Electrophysiology
Volume16
Issue number12
DOIs
Publication statusPublished - 1 Dec 2005

Keywords

  • Atrial fibrillation
  • Catheter ablation
  • Electrophysiology
  • Inducibility

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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