Clinical expert consensus document on standards for acquisition, measurement and reporting of intravascular ultrasound regression/progression studies

Gary S. Mintz, Hector M. Garcia-Garcia, Stephen J. Nicholls, Neil J. Weissman, Nico Bruining, Tim Crowe, Jean Claude Tardif, Patrick W. Serruys

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Atherosclerotic cardiovascular disease is a leading cause of morbidity and mortality despite the widespread use of established medical therapies. This has prompted the search to identify new therapeutic approaches to achieve more effective prevention of cardiovascular events. Considerable interest has focused on the role of surrogate markers of therapeutic efficacy in the early evaluation of novel anti-atherosclerotic therapies. Monitoring changes in the extent of coronary atherosclerosis with intravascular ultrasound (IVUS) has been increasingly employed in clinical trials to assess progression and regression of atherosclerosis. This is based on the pivotal role that atherosclerotic plaque plays in the natural history of cardiovascular disease and the acceptance of validated arterial imaging approaches including coronary angiography and carotid intimal-medial thickness by regulatory authorities. The ability to generate high-resolution imaging of the entire thickness of the coronary artery wall permits evaluation of the entire burden of atherosclerotic plaque. In order to understand the differences, similarities, limitations and pitfalls of the IVUS technique among different academic core laboratories, a number of meetings of representatives from these groups were convened in 2007 and 2008. This document is the result of those IVUS methodology meetings that assembled experts from core laboratories to discuss standards for image acquisition, definitions, criteria, analyses, and primary and secondary endpoints.

LanguageEnglish
Pages1123-1130
Number of pages8
JournalEuroIntervention
Volume6
Issue number9
DOIs
Publication statusPublished - Apr 2011
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Mintz, G. S., Garcia-Garcia, H. M., Nicholls, S. J., Weissman, N. J., Bruining, N., Crowe, T., ... Serruys, P. W. (2011). Clinical expert consensus document on standards for acquisition, measurement and reporting of intravascular ultrasound regression/progression studies. EuroIntervention, 6(9), 1123-1130. https://doi.org/10.4244/EIJV6I9A195
Mintz, Gary S. ; Garcia-Garcia, Hector M. ; Nicholls, Stephen J. ; Weissman, Neil J. ; Bruining, Nico ; Crowe, Tim ; Tardif, Jean Claude ; Serruys, Patrick W. / Clinical expert consensus document on standards for acquisition, measurement and reporting of intravascular ultrasound regression/progression studies. In: EuroIntervention. 2011 ; Vol. 6, No. 9. pp. 1123-1130.
@article{5cc20a0dcccf487da3efd7275142d145,
title = "Clinical expert consensus document on standards for acquisition, measurement and reporting of intravascular ultrasound regression/progression studies",
abstract = "Atherosclerotic cardiovascular disease is a leading cause of morbidity and mortality despite the widespread use of established medical therapies. This has prompted the search to identify new therapeutic approaches to achieve more effective prevention of cardiovascular events. Considerable interest has focused on the role of surrogate markers of therapeutic efficacy in the early evaluation of novel anti-atherosclerotic therapies. Monitoring changes in the extent of coronary atherosclerosis with intravascular ultrasound (IVUS) has been increasingly employed in clinical trials to assess progression and regression of atherosclerosis. This is based on the pivotal role that atherosclerotic plaque plays in the natural history of cardiovascular disease and the acceptance of validated arterial imaging approaches including coronary angiography and carotid intimal-medial thickness by regulatory authorities. The ability to generate high-resolution imaging of the entire thickness of the coronary artery wall permits evaluation of the entire burden of atherosclerotic plaque. In order to understand the differences, similarities, limitations and pitfalls of the IVUS technique among different academic core laboratories, a number of meetings of representatives from these groups were convened in 2007 and 2008. This document is the result of those IVUS methodology meetings that assembled experts from core laboratories to discuss standards for image acquisition, definitions, criteria, analyses, and primary and secondary endpoints.",
author = "Mintz, {Gary S.} and Garcia-Garcia, {Hector M.} and Nicholls, {Stephen J.} and Weissman, {Neil J.} and Nico Bruining and Tim Crowe and Tardif, {Jean Claude} and Serruys, {Patrick W.}",
year = "2011",
month = "4",
doi = "10.4244/EIJV6I9A195",
language = "English",
volume = "6",
pages = "1123--1130",
journal = "EuroIntervention",
issn = "1774-024X",
publisher = "EuroPCR",
number = "9",

}

Mintz, GS, Garcia-Garcia, HM, Nicholls, SJ, Weissman, NJ, Bruining, N, Crowe, T, Tardif, JC & Serruys, PW 2011, 'Clinical expert consensus document on standards for acquisition, measurement and reporting of intravascular ultrasound regression/progression studies', EuroIntervention, vol. 6, no. 9, pp. 1123-1130. https://doi.org/10.4244/EIJV6I9A195

Clinical expert consensus document on standards for acquisition, measurement and reporting of intravascular ultrasound regression/progression studies. / Mintz, Gary S.; Garcia-Garcia, Hector M.; Nicholls, Stephen J.; Weissman, Neil J.; Bruining, Nico; Crowe, Tim; Tardif, Jean Claude; Serruys, Patrick W.

In: EuroIntervention, Vol. 6, No. 9, 04.2011, p. 1123-1130.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical expert consensus document on standards for acquisition, measurement and reporting of intravascular ultrasound regression/progression studies

AU - Mintz, Gary S.

AU - Garcia-Garcia, Hector M.

AU - Nicholls, Stephen J.

AU - Weissman, Neil J.

AU - Bruining, Nico

AU - Crowe, Tim

AU - Tardif, Jean Claude

AU - Serruys, Patrick W.

PY - 2011/4

Y1 - 2011/4

N2 - Atherosclerotic cardiovascular disease is a leading cause of morbidity and mortality despite the widespread use of established medical therapies. This has prompted the search to identify new therapeutic approaches to achieve more effective prevention of cardiovascular events. Considerable interest has focused on the role of surrogate markers of therapeutic efficacy in the early evaluation of novel anti-atherosclerotic therapies. Monitoring changes in the extent of coronary atherosclerosis with intravascular ultrasound (IVUS) has been increasingly employed in clinical trials to assess progression and regression of atherosclerosis. This is based on the pivotal role that atherosclerotic plaque plays in the natural history of cardiovascular disease and the acceptance of validated arterial imaging approaches including coronary angiography and carotid intimal-medial thickness by regulatory authorities. The ability to generate high-resolution imaging of the entire thickness of the coronary artery wall permits evaluation of the entire burden of atherosclerotic plaque. In order to understand the differences, similarities, limitations and pitfalls of the IVUS technique among different academic core laboratories, a number of meetings of representatives from these groups were convened in 2007 and 2008. This document is the result of those IVUS methodology meetings that assembled experts from core laboratories to discuss standards for image acquisition, definitions, criteria, analyses, and primary and secondary endpoints.

AB - Atherosclerotic cardiovascular disease is a leading cause of morbidity and mortality despite the widespread use of established medical therapies. This has prompted the search to identify new therapeutic approaches to achieve more effective prevention of cardiovascular events. Considerable interest has focused on the role of surrogate markers of therapeutic efficacy in the early evaluation of novel anti-atherosclerotic therapies. Monitoring changes in the extent of coronary atherosclerosis with intravascular ultrasound (IVUS) has been increasingly employed in clinical trials to assess progression and regression of atherosclerosis. This is based on the pivotal role that atherosclerotic plaque plays in the natural history of cardiovascular disease and the acceptance of validated arterial imaging approaches including coronary angiography and carotid intimal-medial thickness by regulatory authorities. The ability to generate high-resolution imaging of the entire thickness of the coronary artery wall permits evaluation of the entire burden of atherosclerotic plaque. In order to understand the differences, similarities, limitations and pitfalls of the IVUS technique among different academic core laboratories, a number of meetings of representatives from these groups were convened in 2007 and 2008. This document is the result of those IVUS methodology meetings that assembled experts from core laboratories to discuss standards for image acquisition, definitions, criteria, analyses, and primary and secondary endpoints.

UR - http://www.scopus.com/inward/record.url?scp=80051633878&partnerID=8YFLogxK

U2 - 10.4244/EIJV6I9A195

DO - 10.4244/EIJV6I9A195

M3 - Article

VL - 6

SP - 1123

EP - 1130

JO - EuroIntervention

T2 - EuroIntervention

JF - EuroIntervention

SN - 1774-024X

IS - 9

ER -