Clinical characteristics and outcomes of bilateral breast cancer in an Australian cohort

K. R. Beckmann, J. Buckingham, P. Craft, J. E. Dahlstrom, Y. Zhang, D. Roder, R. Stuart-Harris

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Purpose: Uncertainty remains about the impact of bilateral breast cancer. Characteristics and outcomes of unilateral and bilateral breast cancer were compared within an Australian multi-institutional cohort. Methods: Demographic, tumour and treatment characteristics were compared among unilateral (n = 2336) and bilateral cases (52 synchronous, 35 metachronous) using descriptive analyses. Disease-specific outcomes were investigated using Cox regression modelling to adjust for prognostic and treatment factors. Results: Factors associated with increased risk of bilateral breast cancer included lobular histology (p = 0.046), family history (p = 0.025) and metropolitan residence (p = 0.006). Mastectomy was more common for bilateral cases (p = 0.001) while radiotherapy was less common (p = 0.015). Index metachronous cases were less likely to receive hormonal therapy (p = 0.001). Five-year survivals for metachronous, synchronous and unilateral cases were 79%, 88% and 94%, respectively. Poorer outcomes remained after adjusting for prognostic factors [HR = 2.26, 1.21-4.21]. Conclusion: Our results confirm international findings indicating worse outcomes from bilateral compared with unilateral breast cancer.

LanguageEnglish
Pages158-164
Number of pages7
JournalBreast
Volume20
Issue number2
DOIs
Publication statusPublished - 1 Jan 2011
Externally publishedYes

Keywords

  • Bilateral
  • Breast neoplasm
  • Epidemiology
  • Survival

ASJC Scopus subject areas

  • Surgery

Cite this

Beckmann, K. R., Buckingham, J., Craft, P., Dahlstrom, J. E., Zhang, Y., Roder, D., & Stuart-Harris, R. (2011). Clinical characteristics and outcomes of bilateral breast cancer in an Australian cohort. Breast, 20(2), 158-164. https://doi.org/10.1016/j.breast.2010.10.004
Beckmann, K. R. ; Buckingham, J. ; Craft, P. ; Dahlstrom, J. E. ; Zhang, Y. ; Roder, D. ; Stuart-Harris, R. / Clinical characteristics and outcomes of bilateral breast cancer in an Australian cohort. In: Breast. 2011 ; Vol. 20, No. 2. pp. 158-164.
@article{3ad32d45c1fd4c97a31a0efbcd890c1e,
title = "Clinical characteristics and outcomes of bilateral breast cancer in an Australian cohort",
abstract = "Purpose: Uncertainty remains about the impact of bilateral breast cancer. Characteristics and outcomes of unilateral and bilateral breast cancer were compared within an Australian multi-institutional cohort. Methods: Demographic, tumour and treatment characteristics were compared among unilateral (n = 2336) and bilateral cases (52 synchronous, 35 metachronous) using descriptive analyses. Disease-specific outcomes were investigated using Cox regression modelling to adjust for prognostic and treatment factors. Results: Factors associated with increased risk of bilateral breast cancer included lobular histology (p = 0.046), family history (p = 0.025) and metropolitan residence (p = 0.006). Mastectomy was more common for bilateral cases (p = 0.001) while radiotherapy was less common (p = 0.015). Index metachronous cases were less likely to receive hormonal therapy (p = 0.001). Five-year survivals for metachronous, synchronous and unilateral cases were 79{\%}, 88{\%} and 94{\%}, respectively. Poorer outcomes remained after adjusting for prognostic factors [HR = 2.26, 1.21-4.21]. Conclusion: Our results confirm international findings indicating worse outcomes from bilateral compared with unilateral breast cancer.",
keywords = "Bilateral, Breast neoplasm, Epidemiology, Survival",
author = "Beckmann, {K. R.} and J. Buckingham and P. Craft and Dahlstrom, {J. E.} and Y. Zhang and D. Roder and R. Stuart-Harris",
year = "2011",
month = "1",
day = "1",
doi = "10.1016/j.breast.2010.10.004",
language = "English",
volume = "20",
pages = "158--164",
journal = "Breast",
issn = "0960-9776",
publisher = "Churchill Livingstone",
number = "2",

}

Beckmann, KR, Buckingham, J, Craft, P, Dahlstrom, JE, Zhang, Y, Roder, D & Stuart-Harris, R 2011, 'Clinical characteristics and outcomes of bilateral breast cancer in an Australian cohort', Breast, vol. 20, no. 2, pp. 158-164. https://doi.org/10.1016/j.breast.2010.10.004

Clinical characteristics and outcomes of bilateral breast cancer in an Australian cohort. / Beckmann, K. R.; Buckingham, J.; Craft, P.; Dahlstrom, J. E.; Zhang, Y.; Roder, D.; Stuart-Harris, R.

In: Breast, Vol. 20, No. 2, 01.01.2011, p. 158-164.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical characteristics and outcomes of bilateral breast cancer in an Australian cohort

AU - Beckmann, K. R.

AU - Buckingham, J.

AU - Craft, P.

AU - Dahlstrom, J. E.

AU - Zhang, Y.

AU - Roder, D.

AU - Stuart-Harris, R.

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Purpose: Uncertainty remains about the impact of bilateral breast cancer. Characteristics and outcomes of unilateral and bilateral breast cancer were compared within an Australian multi-institutional cohort. Methods: Demographic, tumour and treatment characteristics were compared among unilateral (n = 2336) and bilateral cases (52 synchronous, 35 metachronous) using descriptive analyses. Disease-specific outcomes were investigated using Cox regression modelling to adjust for prognostic and treatment factors. Results: Factors associated with increased risk of bilateral breast cancer included lobular histology (p = 0.046), family history (p = 0.025) and metropolitan residence (p = 0.006). Mastectomy was more common for bilateral cases (p = 0.001) while radiotherapy was less common (p = 0.015). Index metachronous cases were less likely to receive hormonal therapy (p = 0.001). Five-year survivals for metachronous, synchronous and unilateral cases were 79%, 88% and 94%, respectively. Poorer outcomes remained after adjusting for prognostic factors [HR = 2.26, 1.21-4.21]. Conclusion: Our results confirm international findings indicating worse outcomes from bilateral compared with unilateral breast cancer.

AB - Purpose: Uncertainty remains about the impact of bilateral breast cancer. Characteristics and outcomes of unilateral and bilateral breast cancer were compared within an Australian multi-institutional cohort. Methods: Demographic, tumour and treatment characteristics were compared among unilateral (n = 2336) and bilateral cases (52 synchronous, 35 metachronous) using descriptive analyses. Disease-specific outcomes were investigated using Cox regression modelling to adjust for prognostic and treatment factors. Results: Factors associated with increased risk of bilateral breast cancer included lobular histology (p = 0.046), family history (p = 0.025) and metropolitan residence (p = 0.006). Mastectomy was more common for bilateral cases (p = 0.001) while radiotherapy was less common (p = 0.015). Index metachronous cases were less likely to receive hormonal therapy (p = 0.001). Five-year survivals for metachronous, synchronous and unilateral cases were 79%, 88% and 94%, respectively. Poorer outcomes remained after adjusting for prognostic factors [HR = 2.26, 1.21-4.21]. Conclusion: Our results confirm international findings indicating worse outcomes from bilateral compared with unilateral breast cancer.

KW - Bilateral

KW - Breast neoplasm

KW - Epidemiology

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=79952627099&partnerID=8YFLogxK

U2 - 10.1016/j.breast.2010.10.004

DO - 10.1016/j.breast.2010.10.004

M3 - Article

VL - 20

SP - 158

EP - 164

JO - Breast

T2 - Breast

JF - Breast

SN - 0960-9776

IS - 2

ER -