Chronic benign neutropenia of infancy associated with asymptomatic cytomegalovirus infection

Luis Perez-Jurado, L. Madero, P. Robles, S. Candela, V. Garcia-de Casasola

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A 7-month-old infant with chronic benign neutropenia and hyperlymphocytosis is reported. The neutrophil count ranged between 320 and 810/mm3 during the first 6 weeks of study. The lymphocyte subpopulations showed a relative increase in the B cell count (33%) and a low T4/T8 ratio (0.78). Leukoagglutinins were not demonstrated. He was found to have an asymptomatic cytomegaloviral infection by culturing the virus from his urine. Before a surgical procedure, he was treated with endovenous immunoglublin showing a temporary reversal of neutropenia (up to 10 000 neutrophils/mm3) as well as an increase in the T4/T8 ratio (1.50). Because of the therapeutic response to the immunoglobulin, an immunopathogenia mechanism for neutropenia is proposed, being cytomegalovirus the possible etiologic agent.

Original languageEnglish
Pages (from-to)359-362
Number of pages4
JournalInternational Pediatrics
Issue number4
Publication statusPublished or Issued - 1 Dec 1991
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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