Chemical modification of multiwalled carbon nanotube with a bifunctional caged ligand for radioactive labelling

Ross W. Ormsby, Tony McNally, Christina A. Mitchell, Anthony Musumeci, Tara Schiller, Peter Halley, Lawrence Gahan, Darren Martin, Suzanne V. Smith, Nicholas J. Dunne

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13 Citations (Scopus)


Carboxyl-functionalized multiwalled carbon nanotubes (MWCNTs) have been successfully radiolabelled with cobalt-57 (57Co) (T1/2 = 270 days) via the attachment of the bifunctional caged ligand MeAMN 3S3sar. In this study MeAMN3S3sar has been synthesized and coupled to MWCNTs to form the conjugate MWCNT-MeAMN3S3sar. Synthesis was confirmed with nuclear magnetic resonance. X-ray photoelectron spectroscopy (XPS) confirmed the conjugation. Non-radioactive labelling of this conjugate was completed with Cu(II) ions to confirm the stability of the MeAMN3S3sar after coupling with the MWCNTs. The complexation of the Cu(II) was also confirmed with XPS. Transmission electron microscopy was used to demonstrate that the coupling reaction had a negligible effect on the size and shape of the MWCNTs. Radiolabelling of the MWCNT-MeAMN3S3sar conjugate and pristine (untreated) MWCNTs (non-specific) with the gamma-emitting radioactive isotope 57Co were compared. The radiolabelling efficiency of the MWCNT-MeAMN3S3sar conjugate was significantly higher (95% vs. 0.1%) (P ≤ 0.001) than for the unconjugated pristine MWCNTs. This will allow for the potential tracking of nanoparticle movement in vitro and in vivo.

Original languageEnglish
Pages (from-to)54-61
Number of pages8
JournalActa Materialia
Publication statusPublished or Issued - Feb 2014
Externally publishedYes


  • Bifunctional caged ligand
  • Multi-walled carbon nanotube
  • Nanoparticle tracking
  • Radioactive labelling

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Polymers and Plastics
  • Metals and Alloys

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