Chapter 23 - Inflammation Genetics of Depression

Michael Musker, Julio Licinio, Ma-Li Wong

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Evidence indicates that inflammatory mediators play a role in the development of major depressive disorder (MDD). MDD is thought to be a multigenic disorder in that many genes are implicated in its development. Genetics has enabled researchers to identify the effects of single-nucleotide polymorphisms in specific inflammatory pathways. The link between these genes and biochemical expression of inflammatory mediators is explored. The advance in genomics is rapidly growing as technology enables us to examine large sections of the human genome in a short period of time. At the same time, laboratories across the world are creating genetic databases, mapping samples on a grand scale, and providing the opportunity to access anonymized MDD clinical and genetic data with relative ease. In the last decade, a combination of candidate gene studies, linkage studies, and genome-wide association studies have started to reveal the inheritance of MDD and the genes responsible.
Original languageEnglish
Title of host publicationInflammation and Immunity in Depression
Subtitle of host publicationBasic Science and Clinical Applications
EditorsBernhard T. Baune
PublisherAustralian Academic Press
Chapter23
Pages411-425
Number of pages15
ISBN (Print)978-0-12-811073-7
DOIs
Publication statusPublished - 1 Jun 2018

Keywords

  • Genotype
  • Phenotype
  • Single-nucleotide polymorphism
  • Proinflammatory cytokines
  • Candidate genes
  • Genome-wide association studies

Cite this

Musker, M., Licinio, J., & Wong, M-L. (2018). Chapter 23 - Inflammation Genetics of Depression. In B. T. Baune (Ed.), Inflammation and Immunity in Depression: Basic Science and Clinical Applications (pp. 411-425). Australian Academic Press. https://doi.org/10.1016/B978-0-12-811073-7.00023-4