Cause of antiretroviral drug changes among patients on antiretroviral therapy at the art center in dessei regional referral hospital, Ethiopia

Anwar Mulugeta Gebremichael, Tesfahunn Chanie

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Beside the fact of poor adherence to antiretroviral drugs in resource limited country, serious adverse effects of the drugs and treatment failure complicate the whole management of antiretroviral therapy. Consequently, treatment modification and discontinuation of therapy has become a common phenomenon and hence limitation of treatment option has turn out the major concern of the future HAART. The aim of the study was to assess the factors responsible for modification of ARV regimen in patients taking ARV drugs. Methods: A cross sectional descriptive study was conducted between January 2007 and December 2007 in Dessie regional referral hospital Result: One hundred twenty two patients switch their first regimen in Dessie regional referral hospital within the study period. The most frequent prescribed first regimens before switch were AZT/3TC/EFV (36%), AZT/3TC/NVP (27%), D 4T/3TC/EFV (19%) and D 4T/3TC/NVP (18%). Toxicity (66%) followed by co-morbidity (14%) and planning pregnancy (11%) were the most common reasons for modification of antiretroviral therapy. The main toxicity was anemia (64 patients)and peripheral neuropathy (11 patients). Conclusion: The proportions of patients who modify HAART in our resource constrained setting present a challenge to the limited treatment options that currently present.

LanguageEnglish
Pages120-125
Number of pages6
JournalInternational Journal of Pharmaceutical Sciences
Volume3
Issue number1
Publication statusPublished - 1 Jan 2012
Externally publishedYes

Keywords

  • Efavirenz
  • Neverapine
  • Stavudine
  • Switch
  • Toxicity
  • Zidovudine

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery

Cite this

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title = "Cause of antiretroviral drug changes among patients on antiretroviral therapy at the art center in dessei regional referral hospital, Ethiopia",
abstract = "Background: Beside the fact of poor adherence to antiretroviral drugs in resource limited country, serious adverse effects of the drugs and treatment failure complicate the whole management of antiretroviral therapy. Consequently, treatment modification and discontinuation of therapy has become a common phenomenon and hence limitation of treatment option has turn out the major concern of the future HAART. The aim of the study was to assess the factors responsible for modification of ARV regimen in patients taking ARV drugs. Methods: A cross sectional descriptive study was conducted between January 2007 and December 2007 in Dessie regional referral hospital Result: One hundred twenty two patients switch their first regimen in Dessie regional referral hospital within the study period. The most frequent prescribed first regimens before switch were AZT/3TC/EFV (36{\%}), AZT/3TC/NVP (27{\%}), D 4T/3TC/EFV (19{\%}) and D 4T/3TC/NVP (18{\%}). Toxicity (66{\%}) followed by co-morbidity (14{\%}) and planning pregnancy (11{\%}) were the most common reasons for modification of antiretroviral therapy. The main toxicity was anemia (64 patients)and peripheral neuropathy (11 patients). Conclusion: The proportions of patients who modify HAART in our resource constrained setting present a challenge to the limited treatment options that currently present.",
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AB - Background: Beside the fact of poor adherence to antiretroviral drugs in resource limited country, serious adverse effects of the drugs and treatment failure complicate the whole management of antiretroviral therapy. Consequently, treatment modification and discontinuation of therapy has become a common phenomenon and hence limitation of treatment option has turn out the major concern of the future HAART. The aim of the study was to assess the factors responsible for modification of ARV regimen in patients taking ARV drugs. Methods: A cross sectional descriptive study was conducted between January 2007 and December 2007 in Dessie regional referral hospital Result: One hundred twenty two patients switch their first regimen in Dessie regional referral hospital within the study period. The most frequent prescribed first regimens before switch were AZT/3TC/EFV (36%), AZT/3TC/NVP (27%), D 4T/3TC/EFV (19%) and D 4T/3TC/NVP (18%). Toxicity (66%) followed by co-morbidity (14%) and planning pregnancy (11%) were the most common reasons for modification of antiretroviral therapy. The main toxicity was anemia (64 patients)and peripheral neuropathy (11 patients). Conclusion: The proportions of patients who modify HAART in our resource constrained setting present a challenge to the limited treatment options that currently present.

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