Cationic peptides: Distribution and mechanisms of resistance

Deirdre A. Devine, Robert Hancock

Research output: Contribution to journalReview article

127 Citations (Scopus)

Abstract

Cationic antimicrobial peptides are observed throughout nature. In mammals they are observed both at epithelial surfaces and within the granules of phagocytic cells. They are an important component of innate defences, since in addition to their ability to kill microorganisms, they are able to modulate inflammatory responses. With respect to their ability to kill bacteria, it is very difficult to isolate resistant mutants. However there are a few known mechanisms of intrinsic resistance, including PhoPQ-dependent and other alterations in lipopolysaccharide structure that influence self promoted uptake, and protease-mediated resistance.

LanguageEnglish
Pages703-714
Number of pages12
JournalCurrent Pharmaceutical Design
Volume8
Issue number9
DOIs
Publication statusPublished - 22 May 2002
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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