Cationic antimicrobial peptides are found throughout nature and are important components of the innate defenses of host organisms against infectious agents. They have very desirable properties as antimicrobials, with some peptides having broad spectrum activity against both Gram-negative and Gram-positive bacteria, fungi and enveloped viruses, as well as anti-endotoxic activity and synergy with conventional antibiotics. Although these peptides are quite large, generally 13 to 26 amino acids in length, recombinant synthesis methods are being created to moderate the cost of manufacture. Variants of natural peptides are currently being developed as therapeutics against topical infections, and two peptides have successfully proceeded through phase II clinical trials.
|Number of pages||5|
|Journal||Current Opinion in Anti-infective Investigational Drugs|
|Publication status||Published or Issued - 28 Apr 2000|
- Cationic peptide
- Peptide synthesis
ASJC Scopus subject areas
- Microbiology (medical)