Cationic antimicrobial peptide antibiotics

Robert Hancock, P. Nair

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)

Abstract

Cationic antimicrobial peptides are found throughout nature and are important components of the innate defenses of host organisms against infectious agents. They have very desirable properties as antimicrobials, with some peptides having broad spectrum activity against both Gram-negative and Gram-positive bacteria, fungi and enveloped viruses, as well as anti-endotoxic activity and synergy with conventional antibiotics. Although these peptides are quite large, generally 13 to 26 amino acids in length, recombinant synthesis methods are being created to moderate the cost of manufacture. Variants of natural peptides are currently being developed as therapeutics against topical infections, and two peptides have successfully proceeded through phase II clinical trials.

Original languageEnglish
Pages (from-to)140-144
Number of pages5
JournalCurrent Opinion in Anti-infective Investigational Drugs
Volume2
Issue number2
Publication statusPublished or Issued - 28 Apr 2000
Externally publishedYes

Keywords

  • Cationic peptide
  • Magainins
  • Peptide synthesis
  • Protegrins

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology (medical)

Cite this