Case study of tacrolimus as an effective treatment for idiopathic membranous glomerulonephritis in pregnancy

G. L. Irish, S. Jesudason

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1 Citation (Scopus)

Abstract

Background: Tacrolimus has been used in pregnant women following transplantation and for management of lupus nephritis. We report a case of successful control of nephrotic syndrome due to membranous glomerulonephritis during pregnancy using tacrolimus. Case report: A 26-year-old female presented with severe nephrotic syndrome in her first pregnancy. Post-partum renal biopsy confirmed idiopathic membranous glomerulonephritis. She had persistent proteinuria of 6 g/day with hypoalbuminaemia despite angiotensin receptor blockade. Treatment with tacrolimus monotherapy led to remission of proteinuria, three months prior to conceiving again. She maintained remission with tacrolimus therapy in pregnancy, resulting in a successful birth outcome. Conclusions: Membranous glomerulonephritis can be successfully and safely managed with tacrolimus monotherapy during pregnancy. This provides an alternative immunosuppressant with a favourable side effect profile suitable for use in women planning a pregnancy when other immunosuppressive drugs should be avoided.

Original languageEnglish
Pages (from-to)148-150
Number of pages3
JournalObstetric Medicine
Volume13
Issue number3
DOIs
Publication statusPublished or Issued - Sep 2020
Externally publishedYes

Keywords

  • Membranous glomerulonephritis
  • nephrotic syndrome
  • proteinuria
  • tacrolimus

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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