Cardiovascular effects of propofol and of thiopentone anaesthesia in the sheep

W. B. Runciman, L. E. Mather, D. G. Selby

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

We have examined the effects on the cardiovascular system and on regional blood flow of propofol and thiopentone when administered with IPPV (FlO2 0.4). A longitudinal study design was used in which 16 studies were performed in eight sheep for 30 min before, during the last 30 min of 70 min anaesthesia, and for 6 h after anaesthesia. During anaesthesia with propofol and thiopentone, mean total body oxygen consumption decreased, respectively, by 47% (P < 0.001) and 24% (P < 0.01) of pre-anaesthesia baseline values, mean heart rate increased by approximately 50% (P < 0.05) with both agents, mean arterial pressures increased by approximately 50% (P < 0.05) with both agents and the mean cardiac output was unaltered with propofol anaesthesia but was decreased by 20% (P < 0.05) with thiopentone anaesthesia. The changes in arterial pressure and heart rate were unexpected and may have been a result of a species-specific effect. Mean hepatic blood flow decreased consistently by a mean of 17% (P < 0.01) during propofol anaesthesia, and inconsistently during thiopentone anaesthesia so that it was not significantly different from baseline values. Mean renal blood flow decreased during propofol anaesthesia by 7% (P < 0.05) and by 27% (P < 0.001) during thiopentone anaesthesia. Whereas most variables returned to baseline values within 2 h after propofol anaesthesia, this took 5 h after thiopentone anaesthesia.

LanguageEnglish
Pages353-359
Number of pages7
JournalBritish Journal of Anaesthesia
Volume65
Issue number3
DOIs
Publication statusPublished - 1 Jan 1990
Externally publishedYes

Keywords

  • Anaesthetics, intravenous: propofol, thiopentone
  • Heart: mean arterial pressure, heart rate, cardiac output
  • Kidney: renal blood flow
  • Liver: hepatic blood flow

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Runciman, W. B. ; Mather, L. E. ; Selby, D. G. / Cardiovascular effects of propofol and of thiopentone anaesthesia in the sheep. In: British Journal of Anaesthesia. 1990 ; Vol. 65, No. 3. pp. 353-359.
@article{8c80925929a84fe3af6592b7af95d59b,
title = "Cardiovascular effects of propofol and of thiopentone anaesthesia in the sheep",
abstract = "We have examined the effects on the cardiovascular system and on regional blood flow of propofol and thiopentone when administered with IPPV (FlO2 0.4). A longitudinal study design was used in which 16 studies were performed in eight sheep for 30 min before, during the last 30 min of 70 min anaesthesia, and for 6 h after anaesthesia. During anaesthesia with propofol and thiopentone, mean total body oxygen consumption decreased, respectively, by 47{\%} (P < 0.001) and 24{\%} (P < 0.01) of pre-anaesthesia baseline values, mean heart rate increased by approximately 50{\%} (P < 0.05) with both agents, mean arterial pressures increased by approximately 50{\%} (P < 0.05) with both agents and the mean cardiac output was unaltered with propofol anaesthesia but was decreased by 20{\%} (P < 0.05) with thiopentone anaesthesia. The changes in arterial pressure and heart rate were unexpected and may have been a result of a species-specific effect. Mean hepatic blood flow decreased consistently by a mean of 17{\%} (P < 0.01) during propofol anaesthesia, and inconsistently during thiopentone anaesthesia so that it was not significantly different from baseline values. Mean renal blood flow decreased during propofol anaesthesia by 7{\%} (P < 0.05) and by 27{\%} (P < 0.001) during thiopentone anaesthesia. Whereas most variables returned to baseline values within 2 h after propofol anaesthesia, this took 5 h after thiopentone anaesthesia.",
keywords = "Anaesthetics, intravenous: propofol, thiopentone, Heart: mean arterial pressure, heart rate, cardiac output, Kidney: renal blood flow, Liver: hepatic blood flow",
author = "Runciman, {W. B.} and Mather, {L. E.} and Selby, {D. G.}",
year = "1990",
month = "1",
day = "1",
doi = "10.1093/bja/65.3.353",
language = "English",
volume = "65",
pages = "353--359",
journal = "British Journal of Anaesthesia",
issn = "0007-0912",
publisher = "Oxford University Press",
number = "3",

}

Cardiovascular effects of propofol and of thiopentone anaesthesia in the sheep. / Runciman, W. B.; Mather, L. E.; Selby, D. G.

In: British Journal of Anaesthesia, Vol. 65, No. 3, 01.01.1990, p. 353-359.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cardiovascular effects of propofol and of thiopentone anaesthesia in the sheep

AU - Runciman, W. B.

AU - Mather, L. E.

AU - Selby, D. G.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - We have examined the effects on the cardiovascular system and on regional blood flow of propofol and thiopentone when administered with IPPV (FlO2 0.4). A longitudinal study design was used in which 16 studies were performed in eight sheep for 30 min before, during the last 30 min of 70 min anaesthesia, and for 6 h after anaesthesia. During anaesthesia with propofol and thiopentone, mean total body oxygen consumption decreased, respectively, by 47% (P < 0.001) and 24% (P < 0.01) of pre-anaesthesia baseline values, mean heart rate increased by approximately 50% (P < 0.05) with both agents, mean arterial pressures increased by approximately 50% (P < 0.05) with both agents and the mean cardiac output was unaltered with propofol anaesthesia but was decreased by 20% (P < 0.05) with thiopentone anaesthesia. The changes in arterial pressure and heart rate were unexpected and may have been a result of a species-specific effect. Mean hepatic blood flow decreased consistently by a mean of 17% (P < 0.01) during propofol anaesthesia, and inconsistently during thiopentone anaesthesia so that it was not significantly different from baseline values. Mean renal blood flow decreased during propofol anaesthesia by 7% (P < 0.05) and by 27% (P < 0.001) during thiopentone anaesthesia. Whereas most variables returned to baseline values within 2 h after propofol anaesthesia, this took 5 h after thiopentone anaesthesia.

AB - We have examined the effects on the cardiovascular system and on regional blood flow of propofol and thiopentone when administered with IPPV (FlO2 0.4). A longitudinal study design was used in which 16 studies were performed in eight sheep for 30 min before, during the last 30 min of 70 min anaesthesia, and for 6 h after anaesthesia. During anaesthesia with propofol and thiopentone, mean total body oxygen consumption decreased, respectively, by 47% (P < 0.001) and 24% (P < 0.01) of pre-anaesthesia baseline values, mean heart rate increased by approximately 50% (P < 0.05) with both agents, mean arterial pressures increased by approximately 50% (P < 0.05) with both agents and the mean cardiac output was unaltered with propofol anaesthesia but was decreased by 20% (P < 0.05) with thiopentone anaesthesia. The changes in arterial pressure and heart rate were unexpected and may have been a result of a species-specific effect. Mean hepatic blood flow decreased consistently by a mean of 17% (P < 0.01) during propofol anaesthesia, and inconsistently during thiopentone anaesthesia so that it was not significantly different from baseline values. Mean renal blood flow decreased during propofol anaesthesia by 7% (P < 0.05) and by 27% (P < 0.001) during thiopentone anaesthesia. Whereas most variables returned to baseline values within 2 h after propofol anaesthesia, this took 5 h after thiopentone anaesthesia.

KW - Anaesthetics, intravenous: propofol, thiopentone

KW - Heart: mean arterial pressure, heart rate, cardiac output

KW - Kidney: renal blood flow

KW - Liver: hepatic blood flow

UR - http://www.scopus.com/inward/record.url?scp=0025024096&partnerID=8YFLogxK

U2 - 10.1093/bja/65.3.353

DO - 10.1093/bja/65.3.353

M3 - Article

VL - 65

SP - 353

EP - 359

JO - British Journal of Anaesthesia

T2 - British Journal of Anaesthesia

JF - British Journal of Anaesthesia

SN - 0007-0912

IS - 3

ER -