Cardiovascular disease risk factors after early-onset preeclampsia, late-onset preeclampsia, and pregnancy-induced hypertension

Jan H W Veerbeek, Wietske Hermes, Anath Y. Breimer, Bas B. Van Rijn, Steven V. Koenen, Ben W. Mol, Arie Franx, Christianne J M De Groot, Maria P H Koster

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

Supplemental Digital Content is available in the text. Observational studies have shown an increased lifetime risk of cardiovascular disease (CVD) in women who experienced a hypertensive disorder in pregnancy. This risk is related to the severity of the pregnancy-related hypertensive disease and gestational age at onset. However, it has not been investigated whether these differences in CVD risk factors are already present at postpartum cardiovascular screening. We evaluated postpartum differences in CVD risk factors in 3 subgroups of patients with a history of hypertensive pregnancy. We compared the prevalence of common CVD risk factors postpartum among 448 women with previous early-onset preeclampsia, 76 women with previous late-onset preeclampsia, and 224 women with previous pregnancy-induced hypertension. Women with previous early-onset preeclampsia were compared with women with late-onset preeclampsia and pregnancy-induced hypertension and had significantly higher fasting blood glucose (5.29 versus 4.80 and 4.83 mmol/L), insulin (9.12 versus 6.31 and 6.7 uIU/L), triglycerides (1.32 versus 1.02 and 0.97 mmol/L), and total cholesterol (5.14 versus 4.73 and 4.73 mmol/L). Almost half of the early-onset preeclampsia women had developed hypertension, as opposed to 39% and 25% of women in the pregnancy-induced hypertension and late-onset preeclampsia groups, respectively. Our data show differences in the prevalence of common modifiable CVD risk factors postpartum and suggest that prevention strategies should be stratified according to severity and gestational age of onset for the hypertensive disorders of pregnancy.

LanguageEnglish
Pages600-606
Number of pages7
JournalHypertension
Volume65
Issue number3
DOIs
Publication statusPublished - 4 Mar 2015

Keywords

  • hypertension
  • prevention

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Veerbeek, J. H. W., Hermes, W., Breimer, A. Y., Van Rijn, B. B., Koenen, S. V., Mol, B. W., ... Koster, M. P. H. (2015). Cardiovascular disease risk factors after early-onset preeclampsia, late-onset preeclampsia, and pregnancy-induced hypertension. Hypertension, 65(3), 600-606. https://doi.org/10.1161/HYPERTENSIONAHA.114.04850
Veerbeek, Jan H W ; Hermes, Wietske ; Breimer, Anath Y. ; Van Rijn, Bas B. ; Koenen, Steven V. ; Mol, Ben W. ; Franx, Arie ; De Groot, Christianne J M ; Koster, Maria P H. / Cardiovascular disease risk factors after early-onset preeclampsia, late-onset preeclampsia, and pregnancy-induced hypertension. In: Hypertension. 2015 ; Vol. 65, No. 3. pp. 600-606.
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Veerbeek, JHW, Hermes, W, Breimer, AY, Van Rijn, BB, Koenen, SV, Mol, BW, Franx, A, De Groot, CJM & Koster, MPH 2015, 'Cardiovascular disease risk factors after early-onset preeclampsia, late-onset preeclampsia, and pregnancy-induced hypertension', Hypertension, vol. 65, no. 3, pp. 600-606. https://doi.org/10.1161/HYPERTENSIONAHA.114.04850

Cardiovascular disease risk factors after early-onset preeclampsia, late-onset preeclampsia, and pregnancy-induced hypertension. / Veerbeek, Jan H W; Hermes, Wietske; Breimer, Anath Y.; Van Rijn, Bas B.; Koenen, Steven V.; Mol, Ben W.; Franx, Arie; De Groot, Christianne J M; Koster, Maria P H.

In: Hypertension, Vol. 65, No. 3, 04.03.2015, p. 600-606.

Research output: Contribution to journalArticle

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