Cardiac magnetic resonance evaluation of left ventricular functional, morphological, and structural features in children and adolescents vs. young adults with isolated left ventricular non-compaction

Gaetano Nucifora, Karthigesh Sree Raman, Daniele Muser, Ranjit Shah, Rebecca Perry, Kama A. Awang Ramli, Joseph B. Selvanayagam

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10 Citations (Scopus)


Aim To investigate the left ventricular (LV) functional, morphological, and structural features revealed by cardiac magnetic resonance (CMR) in children/adolescents with isolated LV non-compaction (iLVNC), and to compare them with those observed in young adults with iLVNC and healthy controls. Methods 56 subjects were included: 12 children/adolescents (mean age 15 ± 3 years, 75% male) and 20 young adults (mean age 35 ± 7 years, 75% male) with first diagnosis of iLVNC, 12 healthy children/adolescents (mean age 15 ± 3 years, 75% male) and 12 healthy young adults (mean age 34 ± 8 years, 75% male). CMR with late gadolinium enhancement (LGE) imaging was performed to evaluate LV function, extent of LV trabeculation, and presence/extent of LV LGE, a surrogate of myocardial fibrosis. Tissue-tracking analysis was applied to assess LV global longitudinal (GLS), circumferential (GCS) and radial (GRS) strain. Results The extent of LVNC and the presence/extent of LV LGE in children/adolescents and young adults with iLVNC were similar. Compared to healthy subjects, young adults with iLVNC had significantly lower LVEF; conversely, no significant difference in this parameter was observed between children/adolescents with iLVNC and healthy subjects. However, compared to healthy subjects, LV strain parameters were lower in both children/adolescents and young adults with iLVNC. Conclusions Complete phenotypic expression, subclinical impairment of myocardial deformation properties, and cardiac injury occur early in iLVNC patients, being already noticeable in the pediatric age group. The application of CMR myocardial deformation imaging permits earlier detection of LV functional impairment in children/adolescents with iLVNC, which would otherwise be missed with standard CMR imaging.

Original languageEnglish
Pages (from-to)68-73
Number of pages6
JournalInternational Journal of Cardiology
Publication statusPublished or Issued - 1 Nov 2017


  • Cardiac magnetic resonance
  • Isolated left ventricular non-compaction
  • Late gadolinium enhancement
  • Myocardial fibrosis
  • Strain
  • Tissue-tracking

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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