Brefeldin A blocks protein glycosylation and RNA replication of vesicular stomatitis virus

Alicia Irurzun, Luis Pérez, Luis Carrasco

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16 Citations (Scopus)

Abstract

Brefeldin A is a macrolide antibiotic that interferes with membrane traffic and blocks the growth of several animal viruses including vesicular stomatitis virus (VSV). The inhibition of VSV by brefeldin A takes place at least at two different steps during the growth cycle: the glycosylation of VSV G protein and the replication of viral genomes. Our results indicate that interference with membrane traffic leads not only to inhibition of viral protein glycosylation, but also to the blockade of virus genome replication in several cytoplasmic RNA-containing viruses.

Original languageEnglish
Pages (from-to)496-500
Number of pages5
JournalFEBS Letters
Volume336
Issue number3
DOIs
Publication statusPublished or Issued - 28 Dec 1993

Keywords

  • Brefeldin A
  • Protein glycosylation
  • RNA replication
  • Vesicular stomatitis virus

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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