Brain endothelial cell infection in children with acute fatal measles

Lisa M. Esolen, Kiyomi Takahashi, Richard T. Johnson, Abraham Vaisberg, Thomas R. Moench, Steven Wesselingh, Diane E. Griffin

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Neurologic diseases are important complications of measles. The role of virus infection of the central nervous system as well as the route of virus entry has been unclear. Five autopsied cases of individuals who died with severe acute measles 3-10 d after the onset of the rash were studied for evidence of viral involvement of the central nervous system. In all cases, in situ hybridization and RT-PCR in situ hybridization techniques showed endothelial cell infection. Immunoperoxidase staining with an anti-ferritin antibody revealed a reactive microgliosis. These data suggest that endothelial cells in the brain are frequently infected during acute fatal measles. This site of infection may provide a portal of entry for virus in individuals who subsequently develop subacute sclerosing panencephalitis or measles inclusion body encephalitis and a target for immunologic reactions in post-measles encephalomyelitis.

Original languageEnglish
Pages (from-to)2478-2481
Number of pages4
JournalJournal of Clinical Investigation
Volume96
Issue number5
DOIs
Publication statusPublished - 1 Jan 1995
Externally publishedYes

Keywords

  • blood-brain barrier
  • encephalomyelitis
  • measles virus
  • microglia
  • subacute sclerosing panencephalitis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Esolen, L. M., Takahashi, K., Johnson, R. T., Vaisberg, A., Moench, T. R., Wesselingh, S., & Griffin, D. E. (1995). Brain endothelial cell infection in children with acute fatal measles. Journal of Clinical Investigation, 96(5), 2478-2481. https://doi.org/10.1172/JCI118306