Bone marrow stromal stem cells: Nature, biology, and potential applications

Paolo Bianco, Mara Riminucci, Stan Gronthos, Pamela Gehron Robey

Research output: Contribution to journalReview article

1599 Citations (Scopus)

Abstract

Bone marrow stromal cells are progenitors of skeletal tissue components such as bone, cartilage, the hematopoiesis-supporting stroma, and adipocytes. In addition, they may be experimentally induced to undergo unorthodox differentiation, possibly forming neural and myogenic cells. As such, they represent an important paradigm of post-natal nonhematopoietic stem cells, and an easy source for potential therapeutic use. Along with an overview of the basics of their biology, we discuss here their potential nature as components of the vascular wall, and the prospects for their use in local and systemic transplantation and gene therapy.

LanguageEnglish
Pages180-192
Number of pages13
JournalStem Cells
Volume19
Issue number3
DOIs
Publication statusPublished - 1 Jan 2001

Keywords

  • Gene therapy
  • Marrow stromal stem cells
  • Microvasculature
  • Pericytes
  • Plasticity
  • Skeleton
  • Somatic cell therapy
  • Stem cells
  • Transplantation

ASJC Scopus subject areas

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

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