Bone marrow stromal stem cells for tissue engineering

Stan Gronthos, Sunday O. Akintoye, Cun Yu Wang, Songtao Shi

Research output: Contribution to journalReview articlepeer-review

50 Citations (Scopus)

Abstract

Although preliminary results have been achieved on many different fronts in applying BMSSC technology to tissue engineering, a tremendous amount of work still confronts researchers in this area. Whilst it is clear that BMSSC-mediated osteogenesis has the capacity to integrate with pre-existing bone tissue, substantial progress in this and other approaches needs to be achieved for the accurate reassembly of functional complex organ systems. Some of the main issues are identification of the optimal precursor cell types, establishment of growth and differentiation conditions that meet safety and good manufacturing practice standards, and manipulation of the surrounding environment to allow transplanted cells to survive and function. Furthermore, parallel progress in the development of novel gene manipulation technologies and inductive biocompatible scaffold/material designs are equally as vital. It is anticipated that a concerted multidiscipline approach is required to facilitate the reality and great potential benefits of cell-based tissue engineering applications.

Original languageEnglish
Pages (from-to)188-195
Number of pages8
JournalPeriodontology 2000
Volume41
Issue number1
DOIs
Publication statusPublished - 1 Jun 2006
Externally publishedYes

ASJC Scopus subject areas

  • Periodontics

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