Quimerismo hemático en gemelos dicigóticos concebidos por fertilización in vitro

Translated title of the contribution: Blood cell chimerism in dizygotic twins conceived by in vitro fertilization

G. Á Martos-Moreno, C. Campos, R. Flores, R. Yturriaga, Luis Perez-Jurado, J. Argente

Research output: Contribution to journalArticle


We present a case of hematopoietic chimerism in dizygotic twins (male and female) conceived by in vitro fertilization (IVF). At 8 years of age a blood karyotype was performed on the female due to the presence of clitoromegaly. Two different lines: 46,XX (53%) and 46,XY (47%) were found. FISH studies confirmed the presence of the SRY gene in 46,XY cells. Karyotyping of the male showed two different lines: 46,XY (58%) and 46,XX (42%). SRY gene was present in 46,XY cells. Microsatellite analyses of blood DNA revealed tetra-allelic contribution at some autosomal loci with similar proportions of maternal and paternal alleles and X/Y chromosome dose. FISH in buccal mucous showed that all cells from the female were 46,XX and those from the male 46,XY. The gonadal karyotype in the female was 46,XX without SRY. Hence, we report 46,XX/46,XY chimerism in dizygotic twins. Blood chimerism was confirmed by performing FISH on the buccal cells of the patients.

Original languageSpanish
Pages (from-to)248-252
Number of pages5
JournalAnales de Pediatria
Issue number4
Publication statusPublished - 1 Oct 2013
Externally publishedYes


  • Chimerism
  • Dizygotic twins
  • Karyotype

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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