Bipolar radiofrequency endometrial ablation compared with hydrothermablation for dysfunctional uterine bleeding: A randomized controlled trial

Josien P M Penninx, Ben Willem Mol, Ruben Engels, Minouche M E Van Rumste, Channa Kleijn, Carolien A M Koks, Roy F P M Kruitwagen, Marlies Y. Bongers

Research output: Contribution to journalArticle

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Abstract

Objective: To compare the effectiveness of two second-generation ablation techniques, bipolar radiofrequency impedance-controlled endometrial ablation and hydrothermablation, in the treatment of menorrhagia. Methods: This study was a double-blind, randomized controlled trial, which took place in a large teaching hospital in The Netherlands with 500 beds. Women with menorrhagia were randomly allocated to bipolar radiofrequency ablation (bipolar group) and hydrothermablation (hydrotherm group). At follow-up, both women and observers remained unaware of the type of treatment that had been performed. The primary outcome was amenorrhea. Secondary outcome measures were patient satisfaction and reintervention. Results: We included 160 women in the study, of which 82 were allocated to the bipolar group and 78 to the hydrotherm group. No complications occurred in either of the treatment groups. After 12 months, 87% (65 of 75) of the patients in the bipolar group were completely satisfied with the result of the treatment compared with 68% (48 of 71) in the hydrotherm group (relative risk 1.3, 95% confidence interval [CI] 1.03-1.6). The amenorrhea rates were 47% (35 of 75) in the bipolar group and 24% (17 of 71) in the hydrotherm group (relative risk 2.0, 95% CI 1.2-3.1). The relative risks for a reintervention in the bipolar group compared with the hydrotherm group was 0.29 (95% CI 0.12-0.67), whereas for hysterectomy, this was 0.49 (95% CI 0.15-1.5). Conclusion: In the treatment of menorrhagia, bipolar radiofrequency endometrial ablation system is superior to hydrothermablation.

LanguageEnglish
Pages819-826
Number of pages8
JournalObstetrics and Gynecology
Volume116
Issue number4
DOIs
Publication statusPublished - 1 Jan 2010

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Penninx, J. P. M., Willem Mol, B., Engels, R., Van Rumste, M. M. E., Kleijn, C., Koks, C. A. M., ... Bongers, M. Y. (2010). Bipolar radiofrequency endometrial ablation compared with hydrothermablation for dysfunctional uterine bleeding: A randomized controlled trial. Obstetrics and Gynecology, 116(4), 819-826. https://doi.org/10.1097/AOG.0b013e3181f2e3e3
Penninx, Josien P M ; Willem Mol, Ben ; Engels, Ruben ; Van Rumste, Minouche M E ; Kleijn, Channa ; Koks, Carolien A M ; Kruitwagen, Roy F P M ; Bongers, Marlies Y. / Bipolar radiofrequency endometrial ablation compared with hydrothermablation for dysfunctional uterine bleeding : A randomized controlled trial. In: Obstetrics and Gynecology. 2010 ; Vol. 116, No. 4. pp. 819-826.
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abstract = "Objective: To compare the effectiveness of two second-generation ablation techniques, bipolar radiofrequency impedance-controlled endometrial ablation and hydrothermablation, in the treatment of menorrhagia. Methods: This study was a double-blind, randomized controlled trial, which took place in a large teaching hospital in The Netherlands with 500 beds. Women with menorrhagia were randomly allocated to bipolar radiofrequency ablation (bipolar group) and hydrothermablation (hydrotherm group). At follow-up, both women and observers remained unaware of the type of treatment that had been performed. The primary outcome was amenorrhea. Secondary outcome measures were patient satisfaction and reintervention. Results: We included 160 women in the study, of which 82 were allocated to the bipolar group and 78 to the hydrotherm group. No complications occurred in either of the treatment groups. After 12 months, 87{\%} (65 of 75) of the patients in the bipolar group were completely satisfied with the result of the treatment compared with 68{\%} (48 of 71) in the hydrotherm group (relative risk 1.3, 95{\%} confidence interval [CI] 1.03-1.6). The amenorrhea rates were 47{\%} (35 of 75) in the bipolar group and 24{\%} (17 of 71) in the hydrotherm group (relative risk 2.0, 95{\%} CI 1.2-3.1). The relative risks for a reintervention in the bipolar group compared with the hydrotherm group was 0.29 (95{\%} CI 0.12-0.67), whereas for hysterectomy, this was 0.49 (95{\%} CI 0.15-1.5). Conclusion: In the treatment of menorrhagia, bipolar radiofrequency endometrial ablation system is superior to hydrothermablation.",
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Penninx, JPM, Willem Mol, B, Engels, R, Van Rumste, MME, Kleijn, C, Koks, CAM, Kruitwagen, RFPM & Bongers, MY 2010, 'Bipolar radiofrequency endometrial ablation compared with hydrothermablation for dysfunctional uterine bleeding: A randomized controlled trial', Obstetrics and Gynecology, vol. 116, no. 4, pp. 819-826. https://doi.org/10.1097/AOG.0b013e3181f2e3e3

Bipolar radiofrequency endometrial ablation compared with hydrothermablation for dysfunctional uterine bleeding : A randomized controlled trial. / Penninx, Josien P M; Willem Mol, Ben; Engels, Ruben; Van Rumste, Minouche M E; Kleijn, Channa; Koks, Carolien A M; Kruitwagen, Roy F P M; Bongers, Marlies Y.

In: Obstetrics and Gynecology, Vol. 116, No. 4, 01.01.2010, p. 819-826.

Research output: Contribution to journalArticle

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T1 - Bipolar radiofrequency endometrial ablation compared with hydrothermablation for dysfunctional uterine bleeding

T2 - Obstetrics and gynecology

AU - Penninx, Josien P M

AU - Willem Mol, Ben

AU - Engels, Ruben

AU - Van Rumste, Minouche M E

AU - Kleijn, Channa

AU - Koks, Carolien A M

AU - Kruitwagen, Roy F P M

AU - Bongers, Marlies Y.

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Objective: To compare the effectiveness of two second-generation ablation techniques, bipolar radiofrequency impedance-controlled endometrial ablation and hydrothermablation, in the treatment of menorrhagia. Methods: This study was a double-blind, randomized controlled trial, which took place in a large teaching hospital in The Netherlands with 500 beds. Women with menorrhagia were randomly allocated to bipolar radiofrequency ablation (bipolar group) and hydrothermablation (hydrotherm group). At follow-up, both women and observers remained unaware of the type of treatment that had been performed. The primary outcome was amenorrhea. Secondary outcome measures were patient satisfaction and reintervention. Results: We included 160 women in the study, of which 82 were allocated to the bipolar group and 78 to the hydrotherm group. No complications occurred in either of the treatment groups. After 12 months, 87% (65 of 75) of the patients in the bipolar group were completely satisfied with the result of the treatment compared with 68% (48 of 71) in the hydrotherm group (relative risk 1.3, 95% confidence interval [CI] 1.03-1.6). The amenorrhea rates were 47% (35 of 75) in the bipolar group and 24% (17 of 71) in the hydrotherm group (relative risk 2.0, 95% CI 1.2-3.1). The relative risks for a reintervention in the bipolar group compared with the hydrotherm group was 0.29 (95% CI 0.12-0.67), whereas for hysterectomy, this was 0.49 (95% CI 0.15-1.5). Conclusion: In the treatment of menorrhagia, bipolar radiofrequency endometrial ablation system is superior to hydrothermablation.

AB - Objective: To compare the effectiveness of two second-generation ablation techniques, bipolar radiofrequency impedance-controlled endometrial ablation and hydrothermablation, in the treatment of menorrhagia. Methods: This study was a double-blind, randomized controlled trial, which took place in a large teaching hospital in The Netherlands with 500 beds. Women with menorrhagia were randomly allocated to bipolar radiofrequency ablation (bipolar group) and hydrothermablation (hydrotherm group). At follow-up, both women and observers remained unaware of the type of treatment that had been performed. The primary outcome was amenorrhea. Secondary outcome measures were patient satisfaction and reintervention. Results: We included 160 women in the study, of which 82 were allocated to the bipolar group and 78 to the hydrotherm group. No complications occurred in either of the treatment groups. After 12 months, 87% (65 of 75) of the patients in the bipolar group were completely satisfied with the result of the treatment compared with 68% (48 of 71) in the hydrotherm group (relative risk 1.3, 95% confidence interval [CI] 1.03-1.6). The amenorrhea rates were 47% (35 of 75) in the bipolar group and 24% (17 of 71) in the hydrotherm group (relative risk 2.0, 95% CI 1.2-3.1). The relative risks for a reintervention in the bipolar group compared with the hydrotherm group was 0.29 (95% CI 0.12-0.67), whereas for hysterectomy, this was 0.49 (95% CI 0.15-1.5). Conclusion: In the treatment of menorrhagia, bipolar radiofrequency endometrial ablation system is superior to hydrothermablation.

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U2 - 10.1097/AOG.0b013e3181f2e3e3

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EP - 826

JO - Obstetrics and gynecology

JF - Obstetrics and gynecology

SN - 0029-7844

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