Biology and clinical relevance of mannose-binding lectin

Daniel L. Worthley, Peter G. Bardy, Charles G. Mullighan

Research output: Contribution to journalArticle

Abstract

Mannose-binding lectin (MBL) has attracted great interest as potential target for passive immunotherapy to prevent or reduce infection in a variety of clinical settings. MBL is a multimeric serum lectin that recognises a broad array of pathogens and initiates complement activation independently of antibody. MBL2, the gene encoding MBL, contains several polymorphisms that influence synthesis, assembly or stability of functional multimeric MBL. Genetically determined MBL deficiency is present in up to 40% of individuals, with up to 8% having profoundly reduced circulating MBL levels. MBL deficiency is usually clinically silent in otherwise healthy individuals, but is associated with the risk and severity of infection when immunity is already compromised. This review provides an overview of the basic biology and genetics of MBL, reviews data regarding MBL disease associations, and discusses the potential clinical utility of MBL replacement therapy.

Original languageEnglish
Pages (from-to)457-465
Number of pages9
JournalDrug Design Reviews Online
Volume2
Issue number6
DOIs
Publication statusPublished - 1 Sep 2005
Externally publishedYes

Keywords

  • Collectins
  • Infection
  • Innate immunity
  • Mannose-binding lectin
  • Polymorphism

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

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