Biodistribution and dosimetry of 195mPt-cisplatin in normal volunteers: Imaging agent for single photon emission computed tomography

Mike Sathekge, J. Wagener, S. V. Smith, N. Soni, B. Marjanovic-Painter, C. Zinn, C. Van de Wiele, Y. D'Asseler, G. Perkins, J. R. Zeevaart

Research output: Contribution to journalArticlepeer-review

Abstract

195m Pt-cisplatin is regarded as a promising imaging agent for optimizing dosage in patients receiving cisplatin chemotherapy. Methods: We investigated the whole-body distribution and radiation dosimetry of 195m Pt-cisplatin in humans. Whole-body scans were obtained up to 144 h after intravenous injection of 112.4 MBq 195m Pt-cisplatin in each of five subjects. Blood samples were taken at various times up to 144 h after injection. Urine was collected up to 114 h after injection for calculation of renal clearance and whole-body clearance. Time/activity curves were generated by fitting the organ-specific geometric mean counts, obtained from regions of interest, on the respective images as a function of the time after injection. OLINDA software package was applied to calculate the absorbed radiation dose for various organs. Results: Most of the activity (32 ± 4%) was excreted in the urine during the first 5 h. The effective clearance half-life derived from extrapolation of the whole-body curve was 40 hours (1.7 days). On average, the highest dos e was received by the kidneys (mean dose received 2.68 ± 1.5 mGy/MBq), followed by the spleen (mean dose received 1.6 ± 0.8 mGy/MBq) followed by the liver (mean dose received 1.45 ± 0.38 mGy/MBq). The estimated mean effective dose for the adult subject was 0.185 ± 0.034 mSv/MBq. Conclusion: 195m Pt-cisplatin proved a safe radiopharmaceutical with a favourable bio distribution for early and delayed imaging of pathology above the diaphragm. The ED obtained was 0.185 ± 0.034 mSv/MBq. The highest organ dose was received by the kidneys (2.68 ± 1.5 mGy/ MBq). © Schattauer 2013.
Original languageEnglish
Pages (from-to)222-227
Number of pages6
JournalNuklearMedizin
Volume52
Issue number6
DOIs
Publication statusPublished or Issued - 2013

Keywords

  • 195mPt-cisplatin
  • Biodistribution
  • Normal volunteers

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