Behavioural and neurodevelopmental outcome of 2-year-old children after preterm premature rupture of membranes: Follow-up of a randomised clinical trial comparing induction of labour and expectant management

Jantien L. Van Der Heyden, Christine Willekes, Anneloes L. Van Baar, Aleid G. Van Wassenaer-Leemhuis, Eva Pajkrt, Martijn A. Oudijk, Martina M. Porath, Hans J. Duvekot, Kitty W M Bloemenkamp, Mariette Groenewout, Mallory Woiski, Bas Nij Bijvank, Caroline J. Bax, Janneke Van 'T Hooft, Marko M. Sikkema, Bettina M C Akerboom, Twan L M Mulder, Jan G. Nijhuis, Ben Willem J Mol, David P. Van Der Ham

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective We recently reported that induction of labour does not improve short term neonatal outcome in women with late preterm premature rupture of membranes (PPROM) as compared to expectant management (PPROMEXIL trial). In this study the neurodevelopmental and behavioural outcome of the children from this trial at 2 years of age was studied. Study design We studied outcome of offspring of women randomised in the PPROMEXIL study. These women had >24 h of ruptured membranes and were between 34 and 37 weeks of pregnancy when they were randomised to induction of labour (IoL) or expectant management (EM). Two years after delivery, the parents received the ages and stages questionnaire (ASQ), the child behaviour checklist (CBCL) and a general questionnaire. Results Follow-up data were obtained from 234 children (121 after IoL, 113 after EM, response rate 59% (44% of the original 532 randomised women)). In the IoL group 16 children (14%) had an abnormal score in ≥1 domains of the ASQ, versus 27 (26%) in the EM group (difference in percentage -11.4 (95% CI -21.9 to -0.98; p = 0.033)). For the CBCL, an abnormal score was found in 13% (n = 15) in the IoL group and in 15% (n = 16) in the EM group (difference in percentage -2.13 (95% CI -11.2 to 6.94; p = 0.645)). Conclusion Although a policy of induction of labour in women with late PPROM does not improve short term neonatal outcome, it might be associated with a decrease in neurodevelopmental difficulties at the age of two years as compared to expectant management. Expectant management did not lead to a difference in behavioural problems.

LanguageEnglish
Pages17-23
Number of pages7
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Volume194
DOIs
Publication statusPublished - 1 Nov 2015

Keywords

  • Behavioural outcome
  • Developmental outcome
  • Follow-up
  • Preterm prelabor rupture of membranes

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Van Der Heyden, Jantien L. ; Willekes, Christine ; Van Baar, Anneloes L. ; Van Wassenaer-Leemhuis, Aleid G. ; Pajkrt, Eva ; Oudijk, Martijn A. ; Porath, Martina M. ; Duvekot, Hans J. ; Bloemenkamp, Kitty W M ; Groenewout, Mariette ; Woiski, Mallory ; Nij Bijvank, Bas ; Bax, Caroline J. ; Van 'T Hooft, Janneke ; Sikkema, Marko M. ; Akerboom, Bettina M C ; Mulder, Twan L M ; Nijhuis, Jan G. ; Mol, Ben Willem J ; Van Der Ham, David P. / Behavioural and neurodevelopmental outcome of 2-year-old children after preterm premature rupture of membranes : Follow-up of a randomised clinical trial comparing induction of labour and expectant management. In: European Journal of Obstetrics and Gynecology and Reproductive Biology. 2015 ; Vol. 194. pp. 17-23.
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title = "Behavioural and neurodevelopmental outcome of 2-year-old children after preterm premature rupture of membranes: Follow-up of a randomised clinical trial comparing induction of labour and expectant management",
abstract = "Objective We recently reported that induction of labour does not improve short term neonatal outcome in women with late preterm premature rupture of membranes (PPROM) as compared to expectant management (PPROMEXIL trial). In this study the neurodevelopmental and behavioural outcome of the children from this trial at 2 years of age was studied. Study design We studied outcome of offspring of women randomised in the PPROMEXIL study. These women had >24 h of ruptured membranes and were between 34 and 37 weeks of pregnancy when they were randomised to induction of labour (IoL) or expectant management (EM). Two years after delivery, the parents received the ages and stages questionnaire (ASQ), the child behaviour checklist (CBCL) and a general questionnaire. Results Follow-up data were obtained from 234 children (121 after IoL, 113 after EM, response rate 59{\%} (44{\%} of the original 532 randomised women)). In the IoL group 16 children (14{\%}) had an abnormal score in ≥1 domains of the ASQ, versus 27 (26{\%}) in the EM group (difference in percentage -11.4 (95{\%} CI -21.9 to -0.98; p = 0.033)). For the CBCL, an abnormal score was found in 13{\%} (n = 15) in the IoL group and in 15{\%} (n = 16) in the EM group (difference in percentage -2.13 (95{\%} CI -11.2 to 6.94; p = 0.645)). Conclusion Although a policy of induction of labour in women with late PPROM does not improve short term neonatal outcome, it might be associated with a decrease in neurodevelopmental difficulties at the age of two years as compared to expectant management. Expectant management did not lead to a difference in behavioural problems.",
keywords = "Behavioural outcome, Developmental outcome, Follow-up, Preterm prelabor rupture of membranes",
author = "{Van Der Heyden}, {Jantien L.} and Christine Willekes and {Van Baar}, {Anneloes L.} and {Van Wassenaer-Leemhuis}, {Aleid G.} and Eva Pajkrt and Oudijk, {Martijn A.} and Porath, {Martina M.} and Duvekot, {Hans J.} and Bloemenkamp, {Kitty W M} and Mariette Groenewout and Mallory Woiski and {Nij Bijvank}, Bas and Bax, {Caroline J.} and {Van 'T Hooft}, Janneke and Sikkema, {Marko M.} and Akerboom, {Bettina M C} and Mulder, {Twan L M} and Nijhuis, {Jan G.} and Mol, {Ben Willem J} and {Van Der Ham}, {David P.}",
year = "2015",
month = "11",
day = "1",
doi = "10.1016/j.ejogrb.2015.07.014",
language = "English",
volume = "194",
pages = "17--23",
journal = "European Journal of Obstetrics Gynecology and Reproductive Biology",
issn = "0301-2115",
publisher = "Elsevier Ireland Ltd",

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Van Der Heyden, JL, Willekes, C, Van Baar, AL, Van Wassenaer-Leemhuis, AG, Pajkrt, E, Oudijk, MA, Porath, MM, Duvekot, HJ, Bloemenkamp, KWM, Groenewout, M, Woiski, M, Nij Bijvank, B, Bax, CJ, Van 'T Hooft, J, Sikkema, MM, Akerboom, BMC, Mulder, TLM, Nijhuis, JG, Mol, BWJ & Van Der Ham, DP 2015, 'Behavioural and neurodevelopmental outcome of 2-year-old children after preterm premature rupture of membranes: Follow-up of a randomised clinical trial comparing induction of labour and expectant management', European Journal of Obstetrics and Gynecology and Reproductive Biology, vol. 194, pp. 17-23. https://doi.org/10.1016/j.ejogrb.2015.07.014

Behavioural and neurodevelopmental outcome of 2-year-old children after preterm premature rupture of membranes : Follow-up of a randomised clinical trial comparing induction of labour and expectant management. / Van Der Heyden, Jantien L.; Willekes, Christine; Van Baar, Anneloes L.; Van Wassenaer-Leemhuis, Aleid G.; Pajkrt, Eva; Oudijk, Martijn A.; Porath, Martina M.; Duvekot, Hans J.; Bloemenkamp, Kitty W M; Groenewout, Mariette; Woiski, Mallory; Nij Bijvank, Bas; Bax, Caroline J.; Van 'T Hooft, Janneke; Sikkema, Marko M.; Akerboom, Bettina M C; Mulder, Twan L M; Nijhuis, Jan G.; Mol, Ben Willem J; Van Der Ham, David P.

In: European Journal of Obstetrics and Gynecology and Reproductive Biology, Vol. 194, 01.11.2015, p. 17-23.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Behavioural and neurodevelopmental outcome of 2-year-old children after preterm premature rupture of membranes

T2 - European Journal of Obstetrics Gynecology and Reproductive Biology

AU - Van Der Heyden, Jantien L.

AU - Willekes, Christine

AU - Van Baar, Anneloes L.

AU - Van Wassenaer-Leemhuis, Aleid G.

AU - Pajkrt, Eva

AU - Oudijk, Martijn A.

AU - Porath, Martina M.

AU - Duvekot, Hans J.

AU - Bloemenkamp, Kitty W M

AU - Groenewout, Mariette

AU - Woiski, Mallory

AU - Nij Bijvank, Bas

AU - Bax, Caroline J.

AU - Van 'T Hooft, Janneke

AU - Sikkema, Marko M.

AU - Akerboom, Bettina M C

AU - Mulder, Twan L M

AU - Nijhuis, Jan G.

AU - Mol, Ben Willem J

AU - Van Der Ham, David P.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Objective We recently reported that induction of labour does not improve short term neonatal outcome in women with late preterm premature rupture of membranes (PPROM) as compared to expectant management (PPROMEXIL trial). In this study the neurodevelopmental and behavioural outcome of the children from this trial at 2 years of age was studied. Study design We studied outcome of offspring of women randomised in the PPROMEXIL study. These women had >24 h of ruptured membranes and were between 34 and 37 weeks of pregnancy when they were randomised to induction of labour (IoL) or expectant management (EM). Two years after delivery, the parents received the ages and stages questionnaire (ASQ), the child behaviour checklist (CBCL) and a general questionnaire. Results Follow-up data were obtained from 234 children (121 after IoL, 113 after EM, response rate 59% (44% of the original 532 randomised women)). In the IoL group 16 children (14%) had an abnormal score in ≥1 domains of the ASQ, versus 27 (26%) in the EM group (difference in percentage -11.4 (95% CI -21.9 to -0.98; p = 0.033)). For the CBCL, an abnormal score was found in 13% (n = 15) in the IoL group and in 15% (n = 16) in the EM group (difference in percentage -2.13 (95% CI -11.2 to 6.94; p = 0.645)). Conclusion Although a policy of induction of labour in women with late PPROM does not improve short term neonatal outcome, it might be associated with a decrease in neurodevelopmental difficulties at the age of two years as compared to expectant management. Expectant management did not lead to a difference in behavioural problems.

AB - Objective We recently reported that induction of labour does not improve short term neonatal outcome in women with late preterm premature rupture of membranes (PPROM) as compared to expectant management (PPROMEXIL trial). In this study the neurodevelopmental and behavioural outcome of the children from this trial at 2 years of age was studied. Study design We studied outcome of offspring of women randomised in the PPROMEXIL study. These women had >24 h of ruptured membranes and were between 34 and 37 weeks of pregnancy when they were randomised to induction of labour (IoL) or expectant management (EM). Two years after delivery, the parents received the ages and stages questionnaire (ASQ), the child behaviour checklist (CBCL) and a general questionnaire. Results Follow-up data were obtained from 234 children (121 after IoL, 113 after EM, response rate 59% (44% of the original 532 randomised women)). In the IoL group 16 children (14%) had an abnormal score in ≥1 domains of the ASQ, versus 27 (26%) in the EM group (difference in percentage -11.4 (95% CI -21.9 to -0.98; p = 0.033)). For the CBCL, an abnormal score was found in 13% (n = 15) in the IoL group and in 15% (n = 16) in the EM group (difference in percentage -2.13 (95% CI -11.2 to 6.94; p = 0.645)). Conclusion Although a policy of induction of labour in women with late PPROM does not improve short term neonatal outcome, it might be associated with a decrease in neurodevelopmental difficulties at the age of two years as compared to expectant management. Expectant management did not lead to a difference in behavioural problems.

KW - Behavioural outcome

KW - Developmental outcome

KW - Follow-up

KW - Preterm prelabor rupture of membranes

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U2 - 10.1016/j.ejogrb.2015.07.014

DO - 10.1016/j.ejogrb.2015.07.014

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