Bayesian segmentation using residue proximity for secondary structure and contact prediction

Niranjan Bidargaddi, M. Chetty, J. Kamruzzaman

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Secondary structure, residue contacts and contact numbers play an important role in tertiary structure determination of proteins. In the recent past, mainly due to non local interactions, Bayesian segmentation approach has been successfully used for secondary structure prediction. In this paper, the performance of the Bayesian segmentation approach has been enhanced by taking residue contacts into account. The three state prediction accuracy increased by 2% when residue contacts were taken into account. Due to the inherent flexibility the Bayesian segmentation approach has been extended to infer residue contacts and contact numbers with the same segmentations. The proposed method achieved CorR values greater than 0.70 for protein sequence 1a62 and 1aba.

Original languageEnglish
Title of host publicationProceedings of the 2006 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB'06
Pages79-86
Number of pages8
DOIs
Publication statusPublished - 1 Dec 2006
Externally publishedYes
Event3rd Computational Intelligence in Bioinformatics and Computational Biology Symposium, CIBCB - Toronto, ON, Canada
Duration: 28 Sep 200629 Sep 2006

Other

Other3rd Computational Intelligence in Bioinformatics and Computational Biology Symposium, CIBCB
CountryCanada
CityToronto, ON
Period28/09/0629/09/06

ASJC Scopus subject areas

  • Artificial Intelligence
  • Biomedical Engineering
  • Applied Mathematics
  • Computational Mathematics

Cite this

Bidargaddi, N., Chetty, M., & Kamruzzaman, J. (2006). Bayesian segmentation using residue proximity for secondary structure and contact prediction. In Proceedings of the 2006 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB'06 (pp. 79-86). [4133157] https://doi.org/10.1109/CIBCB.2006.331015