Axonal and neuronal amyloid precursor protein immunoreactivity in the brains of guinea pigs given tunicamycin

J. W. Finnie, J. Manavis, P. C. Blumbergs, T. R. Kuchel

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

Amyloid precursor protein (APP) immunocytochemistry was used to study axonal and neuronal changes in guinea pig brains exposed to tunicamycin. Substantial axonal injury was found in ischemic-hypoxic foci and more generally, but this injury was not readily appreciable in conventionally stained sections. Neuronal perikaryal APP expression was also widely distributed, possibly as an acute phase response to this neurotoxin.

Original languageEnglish
Pages (from-to)677-680
Number of pages4
JournalVeterinary Pathology
Volume37
Issue number6
DOIs
Publication statusPublished - Nov 2000

Keywords

  • Amyloid precursor protein immunohistochemistry
  • Axonal and neuronal changes
  • Brain
  • Guinea pigs
  • Tunicamycin

ASJC Scopus subject areas

  • veterinary(all)

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