Autoimmune haemolytic anaemia as the presenting manifestation of agnogenic myeloid metaplasia

Unmesh Mohite, Anil Pathare, Salam Al Kindi, Devendra Hiwase, Nirmala Vadakkepat, Huxley Knox-Macaulay

Research output: Contribution to journalArticle

Abstract

We report an unusual case of a 40-year-old female patient with a severe case of direct Coombs positive haemolytic anaemia, moderate hepatomegaly and marked splenomegaly. Her initial response to steroids was transient and was rapidly followed by a relapse. Therefore, she underwent splenectomy both as a therapeutic measure and to rule out an underlying lymphoproliferative disorder. Histopathological examination of the excised spleen, as well a liver biopsy, revealed extensive extramedullary haematopoiesis, while significant marrow fibrosis was noted in a trephine biopsy sample. These findings confirmed the concomitant diagnosis of agnogenic myeloid metaplasia with myelofibrosis.

LanguageEnglish
Pages495-499
Number of pages5
JournalHaematologia
Volume32
Issue number4
Publication statusPublished - 1 Dec 2002
Externally publishedYes

ASJC Scopus subject areas

  • Hematology

Cite this

Mohite, U., Pathare, A., Al Kindi, S., Hiwase, D., Vadakkepat, N., & Knox-Macaulay, H. (2002). Autoimmune haemolytic anaemia as the presenting manifestation of agnogenic myeloid metaplasia. Haematologia, 32(4), 495-499.