Atherosclerosis imaging in drug development

Stephen J. Nicholls, Srinivasa Kalidindi, Keon Woong Moon, Steven E. Nissen

Research output: Contribution to journalReview article

Abstract

Increasing use of established medical therapies presents a major challenge for the assessment of experimental antiatherosclerotic agents. The requirement to perform clinical trials with increasing numbers of subjects, followed for longer periods of time, creates a scenario that is largely prohibitive for the development of most new agents. Technologic advances in arterial wall imaging provide the opportunity to evaluate the impact of therapies on the natural history of atherosclerosis. The design and implementation of clinical trials that employ serial imaging of the arterial wall has become increasingly used in the development of new therapies to target atherosclerotic cardiovascular disease.

LanguageEnglish
Pages1241-1250
Number of pages10
JournalExpert Opinion on Drug Discovery
Volume2
Issue number9
DOIs
Publication statusPublished - 1 Sep 2007

Keywords

  • Atherosclerosis
  • Drug development
  • Imaging
  • Risk factor

ASJC Scopus subject areas

  • Drug Discovery

Cite this

Nicholls, S. J., Kalidindi, S., Moon, K. W., & Nissen, S. E. (2007). Atherosclerosis imaging in drug development. Expert Opinion on Drug Discovery, 2(9), 1241-1250. https://doi.org/10.1517/17460441.2.9.1241