Associations of ABCG1-mediated cholesterol efflux capacity with coronary artery lipid content assessed by near-infrared spectroscopy

Kohei Takata, Satoshi Honda, Samuel L. Sidharta, My Ngan Duong, Daisuke Shishikura, Susan W. Kim, Jordan Andrews, Belinda A. Di Bartolo, Peter Psaltis, Christina Bursill, Matthew I. Worthley, Stephen J. Nicholls

Research output: Contribution to journalArticle

Abstract

Background: Although high-density lipoprotein (HDL) has atheroprotective properties, the association of HDL functionality with coronary plaques remains unclear. Methods: We investigated the association between HDL-mediated cholesterol efflux capacity (CEC) and coronary lipid burden in 74 patients who underwent near-infrared spectroscopy (NIRS) imaging for acute coronary syndrome (ACS) or stable ischemic symptoms. We measured baseline HDL-mediated CEC, distinguishing the specific pathways, and stratified patients according to their median CEC values. Coronary lipid burden was assessed as lipid core burden index (LCBI) using NIRS at baseline (n=74) and on serial imaging (n=47). Results: Patients with baseline ATP-binding cassette transporter G1 (ABCG1)-mediated CEC > median had a greater baseline LCBI {74 [20, 128] vs. 32 [5, 66]; P=0.04} or change in LCBI {−30 [−89, 0] vs. −3 [−16, 0]; P=0.048}. In addition to a negative association between baseline LCBI and change in LCBI (standardized β=−0.31; P=0.02), multivariable analysis demonstrated a significant interaction effect between clinical presentation of coronary artery disease (CAD) and baseline ABCG1-mediated CEC on change in LCBI (P=0.003), indicating that baseline ABCG1-mediated CEC was inversely associated with change in LCBI in patients with ACS (standardized β=−0.79, P=0.003), but not in those with stable ischemic symptoms (P=0.52). Conclusions: In this study, ABCG1-mediated CEC, but not ATP-binding cassette transporter A1 and scavenger receptor B type I, was associated with regression of coronary artery lipid content, especially in patients with high-risk phenotype. Further studies are required to determine the roles of ABCG1 pathway in the development coronary plaques.

LanguageEnglish
Pages310-318
Number of pages9
JournalCardiovascular Diagnosis and Therapy
Volume9
Issue number4
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • ATP-binding cassette transporter G1
  • Cholesterol efflux
  • Coronary artery lipid content
  • High-density lipoprotein (HDL)
  • Near-infrared spectroscopy (NIRS)

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Takata, Kohei ; Honda, Satoshi ; Sidharta, Samuel L. ; Duong, My Ngan ; Shishikura, Daisuke ; Kim, Susan W. ; Andrews, Jordan ; Di Bartolo, Belinda A. ; Psaltis, Peter ; Bursill, Christina ; Worthley, Matthew I. ; Nicholls, Stephen J. / Associations of ABCG1-mediated cholesterol efflux capacity with coronary artery lipid content assessed by near-infrared spectroscopy. In: Cardiovascular Diagnosis and Therapy. 2019 ; Vol. 9, No. 4. pp. 310-318.
@article{74d786e6faca4f0a8508feac1cf01f36,
title = "Associations of ABCG1-mediated cholesterol efflux capacity with coronary artery lipid content assessed by near-infrared spectroscopy",
abstract = "Background: Although high-density lipoprotein (HDL) has atheroprotective properties, the association of HDL functionality with coronary plaques remains unclear. Methods: We investigated the association between HDL-mediated cholesterol efflux capacity (CEC) and coronary lipid burden in 74 patients who underwent near-infrared spectroscopy (NIRS) imaging for acute coronary syndrome (ACS) or stable ischemic symptoms. We measured baseline HDL-mediated CEC, distinguishing the specific pathways, and stratified patients according to their median CEC values. Coronary lipid burden was assessed as lipid core burden index (LCBI) using NIRS at baseline (n=74) and on serial imaging (n=47). Results: Patients with baseline ATP-binding cassette transporter G1 (ABCG1)-mediated CEC > median had a greater baseline LCBI {74 [20, 128] vs. 32 [5, 66]; P=0.04} or change in LCBI {−30 [−89, 0] vs. −3 [−16, 0]; P=0.048}. In addition to a negative association between baseline LCBI and change in LCBI (standardized β=−0.31; P=0.02), multivariable analysis demonstrated a significant interaction effect between clinical presentation of coronary artery disease (CAD) and baseline ABCG1-mediated CEC on change in LCBI (P=0.003), indicating that baseline ABCG1-mediated CEC was inversely associated with change in LCBI in patients with ACS (standardized β=−0.79, P=0.003), but not in those with stable ischemic symptoms (P=0.52). Conclusions: In this study, ABCG1-mediated CEC, but not ATP-binding cassette transporter A1 and scavenger receptor B type I, was associated with regression of coronary artery lipid content, especially in patients with high-risk phenotype. Further studies are required to determine the roles of ABCG1 pathway in the development coronary plaques.",
keywords = "ATP-binding cassette transporter G1, Cholesterol efflux, Coronary artery lipid content, High-density lipoprotein (HDL), Near-infrared spectroscopy (NIRS)",
author = "Kohei Takata and Satoshi Honda and Sidharta, {Samuel L.} and Duong, {My Ngan} and Daisuke Shishikura and Kim, {Susan W.} and Jordan Andrews and {Di Bartolo}, {Belinda A.} and Peter Psaltis and Christina Bursill and Worthley, {Matthew I.} and Nicholls, {Stephen J.}",
year = "2019",
month = "1",
day = "1",
doi = "10.21037/cdt.2018.11.04",
language = "English",
volume = "9",
pages = "310--318",
journal = "Cardiovascular Diagnosis and Therapy",
issn = "2223-3652",
publisher = "AME Publishing Company",
number = "4",

}

Associations of ABCG1-mediated cholesterol efflux capacity with coronary artery lipid content assessed by near-infrared spectroscopy. / Takata, Kohei; Honda, Satoshi; Sidharta, Samuel L.; Duong, My Ngan; Shishikura, Daisuke; Kim, Susan W.; Andrews, Jordan; Di Bartolo, Belinda A.; Psaltis, Peter; Bursill, Christina; Worthley, Matthew I.; Nicholls, Stephen J.

In: Cardiovascular Diagnosis and Therapy, Vol. 9, No. 4, 01.01.2019, p. 310-318.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Associations of ABCG1-mediated cholesterol efflux capacity with coronary artery lipid content assessed by near-infrared spectroscopy

AU - Takata, Kohei

AU - Honda, Satoshi

AU - Sidharta, Samuel L.

AU - Duong, My Ngan

AU - Shishikura, Daisuke

AU - Kim, Susan W.

AU - Andrews, Jordan

AU - Di Bartolo, Belinda A.

AU - Psaltis, Peter

AU - Bursill, Christina

AU - Worthley, Matthew I.

AU - Nicholls, Stephen J.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Although high-density lipoprotein (HDL) has atheroprotective properties, the association of HDL functionality with coronary plaques remains unclear. Methods: We investigated the association between HDL-mediated cholesterol efflux capacity (CEC) and coronary lipid burden in 74 patients who underwent near-infrared spectroscopy (NIRS) imaging for acute coronary syndrome (ACS) or stable ischemic symptoms. We measured baseline HDL-mediated CEC, distinguishing the specific pathways, and stratified patients according to their median CEC values. Coronary lipid burden was assessed as lipid core burden index (LCBI) using NIRS at baseline (n=74) and on serial imaging (n=47). Results: Patients with baseline ATP-binding cassette transporter G1 (ABCG1)-mediated CEC > median had a greater baseline LCBI {74 [20, 128] vs. 32 [5, 66]; P=0.04} or change in LCBI {−30 [−89, 0] vs. −3 [−16, 0]; P=0.048}. In addition to a negative association between baseline LCBI and change in LCBI (standardized β=−0.31; P=0.02), multivariable analysis demonstrated a significant interaction effect between clinical presentation of coronary artery disease (CAD) and baseline ABCG1-mediated CEC on change in LCBI (P=0.003), indicating that baseline ABCG1-mediated CEC was inversely associated with change in LCBI in patients with ACS (standardized β=−0.79, P=0.003), but not in those with stable ischemic symptoms (P=0.52). Conclusions: In this study, ABCG1-mediated CEC, but not ATP-binding cassette transporter A1 and scavenger receptor B type I, was associated with regression of coronary artery lipid content, especially in patients with high-risk phenotype. Further studies are required to determine the roles of ABCG1 pathway in the development coronary plaques.

AB - Background: Although high-density lipoprotein (HDL) has atheroprotective properties, the association of HDL functionality with coronary plaques remains unclear. Methods: We investigated the association between HDL-mediated cholesterol efflux capacity (CEC) and coronary lipid burden in 74 patients who underwent near-infrared spectroscopy (NIRS) imaging for acute coronary syndrome (ACS) or stable ischemic symptoms. We measured baseline HDL-mediated CEC, distinguishing the specific pathways, and stratified patients according to their median CEC values. Coronary lipid burden was assessed as lipid core burden index (LCBI) using NIRS at baseline (n=74) and on serial imaging (n=47). Results: Patients with baseline ATP-binding cassette transporter G1 (ABCG1)-mediated CEC > median had a greater baseline LCBI {74 [20, 128] vs. 32 [5, 66]; P=0.04} or change in LCBI {−30 [−89, 0] vs. −3 [−16, 0]; P=0.048}. In addition to a negative association between baseline LCBI and change in LCBI (standardized β=−0.31; P=0.02), multivariable analysis demonstrated a significant interaction effect between clinical presentation of coronary artery disease (CAD) and baseline ABCG1-mediated CEC on change in LCBI (P=0.003), indicating that baseline ABCG1-mediated CEC was inversely associated with change in LCBI in patients with ACS (standardized β=−0.79, P=0.003), but not in those with stable ischemic symptoms (P=0.52). Conclusions: In this study, ABCG1-mediated CEC, but not ATP-binding cassette transporter A1 and scavenger receptor B type I, was associated with regression of coronary artery lipid content, especially in patients with high-risk phenotype. Further studies are required to determine the roles of ABCG1 pathway in the development coronary plaques.

KW - ATP-binding cassette transporter G1

KW - Cholesterol efflux

KW - Coronary artery lipid content

KW - High-density lipoprotein (HDL)

KW - Near-infrared spectroscopy (NIRS)

UR - http://www.scopus.com/inward/record.url?scp=85072307138&partnerID=8YFLogxK

U2 - 10.21037/cdt.2018.11.04

DO - 10.21037/cdt.2018.11.04

M3 - Article

VL - 9

SP - 310

EP - 318

JO - Cardiovascular Diagnosis and Therapy

T2 - Cardiovascular Diagnosis and Therapy

JF - Cardiovascular Diagnosis and Therapy

SN - 2223-3652

IS - 4

ER -