Associations between periodontal disease and cardiovascular surrogate measures among Indigenous Australians

Kostas Kapellas, Lisa M. Jamieson, Loc G. Do, P. Mark Bartold, Hao Wang, Louise J. Maple-Brown, David Sullivan, Kerin O'Dea, Alex Brown, David S. Celermajer, Gary D. Slade, Michael R. Skilton

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background/objectives Inflammation is a key pathogenetic factor in atherogenesis. Periodontitis is a chronic inflammatory source which can have systemic impacts. Indigenous Australians have a higher prevalence of periodontal disease and experience cardiovascular disease earlier than non-Indigenous Australians. The aim was to describe the association between severity of periodontal inflammatory disease and measures of arterial structure and function. Methods Periodontal disease in a convenience sample of Indigenous Australians was assessed clinically; for those with periodontal disease, the extent of periodontal pockets ≤ 4 mm was stratified into quartiles. Vascular health was measured non-invasively via carotid-dorsalis pedis pulse-wave velocity (PWV), and via B-mode ultrasound of the common carotid intima-media (IMT). Non-fasting blood samples were collected for lipid and inflammatory marker evaluation. Linear regression models were constructed to determine the associations between extent of periodontal pocketing and vascular health, adjusting for traditional cardiovascular common risk factors. Results 273 Indigenous Australian adults were recruited and complete data was available for 269 participants (154 males), median age 39 years. Arterial stiffness (PWV) significantly increased with increasing extent of periodontal pocketing (p trend = 0.001). By contrast, carotid IMT did not differ across quartiles. Conclusions Periodontal pocketing was associated with central arterial stiffness, a marker of presymptomatic arterial dysfunction, in Indigenous Australian adults with periodontal disease.

LanguageEnglish
Pages190-196
Number of pages7
JournalInternational Journal of Cardiology
Volume173
Issue number2
DOIs
Publication statusPublished - 1 May 2014

Keywords

  • Aboriginal
  • Arterial stiffening
  • Periodontal disease
  • Smoking
  • Type 2 diabetes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Kapellas, K., Jamieson, L. M., Do, L. G., Bartold, P. M., Wang, H., Maple-Brown, L. J., ... Skilton, M. R. (2014). Associations between periodontal disease and cardiovascular surrogate measures among Indigenous Australians. International Journal of Cardiology, 173(2), 190-196. https://doi.org/10.1016/j.ijcard.2014.02.015
Kapellas, Kostas ; Jamieson, Lisa M. ; Do, Loc G. ; Bartold, P. Mark ; Wang, Hao ; Maple-Brown, Louise J. ; Sullivan, David ; O'Dea, Kerin ; Brown, Alex ; Celermajer, David S. ; Slade, Gary D. ; Skilton, Michael R. / Associations between periodontal disease and cardiovascular surrogate measures among Indigenous Australians. In: International Journal of Cardiology. 2014 ; Vol. 173, No. 2. pp. 190-196.
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abstract = "Background/objectives Inflammation is a key pathogenetic factor in atherogenesis. Periodontitis is a chronic inflammatory source which can have systemic impacts. Indigenous Australians have a higher prevalence of periodontal disease and experience cardiovascular disease earlier than non-Indigenous Australians. The aim was to describe the association between severity of periodontal inflammatory disease and measures of arterial structure and function. Methods Periodontal disease in a convenience sample of Indigenous Australians was assessed clinically; for those with periodontal disease, the extent of periodontal pockets ≤ 4 mm was stratified into quartiles. Vascular health was measured non-invasively via carotid-dorsalis pedis pulse-wave velocity (PWV), and via B-mode ultrasound of the common carotid intima-media (IMT). Non-fasting blood samples were collected for lipid and inflammatory marker evaluation. Linear regression models were constructed to determine the associations between extent of periodontal pocketing and vascular health, adjusting for traditional cardiovascular common risk factors. Results 273 Indigenous Australian adults were recruited and complete data was available for 269 participants (154 males), median age 39 years. Arterial stiffness (PWV) significantly increased with increasing extent of periodontal pocketing (p trend = 0.001). By contrast, carotid IMT did not differ across quartiles. Conclusions Periodontal pocketing was associated with central arterial stiffness, a marker of presymptomatic arterial dysfunction, in Indigenous Australian adults with periodontal disease.",
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Kapellas, K, Jamieson, LM, Do, LG, Bartold, PM, Wang, H, Maple-Brown, LJ, Sullivan, D, O'Dea, K, Brown, A, Celermajer, DS, Slade, GD & Skilton, MR 2014, 'Associations between periodontal disease and cardiovascular surrogate measures among Indigenous Australians', International Journal of Cardiology, vol. 173, no. 2, pp. 190-196. https://doi.org/10.1016/j.ijcard.2014.02.015

Associations between periodontal disease and cardiovascular surrogate measures among Indigenous Australians. / Kapellas, Kostas; Jamieson, Lisa M.; Do, Loc G.; Bartold, P. Mark; Wang, Hao; Maple-Brown, Louise J.; Sullivan, David; O'Dea, Kerin; Brown, Alex; Celermajer, David S.; Slade, Gary D.; Skilton, Michael R.

In: International Journal of Cardiology, Vol. 173, No. 2, 01.05.2014, p. 190-196.

Research output: Contribution to journalArticle

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AU - Kapellas, Kostas

AU - Jamieson, Lisa M.

AU - Do, Loc G.

AU - Bartold, P. Mark

AU - Wang, Hao

AU - Maple-Brown, Louise J.

AU - Sullivan, David

AU - O'Dea, Kerin

AU - Brown, Alex

AU - Celermajer, David S.

AU - Slade, Gary D.

AU - Skilton, Michael R.

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N2 - Background/objectives Inflammation is a key pathogenetic factor in atherogenesis. Periodontitis is a chronic inflammatory source which can have systemic impacts. Indigenous Australians have a higher prevalence of periodontal disease and experience cardiovascular disease earlier than non-Indigenous Australians. The aim was to describe the association between severity of periodontal inflammatory disease and measures of arterial structure and function. Methods Periodontal disease in a convenience sample of Indigenous Australians was assessed clinically; for those with periodontal disease, the extent of periodontal pockets ≤ 4 mm was stratified into quartiles. Vascular health was measured non-invasively via carotid-dorsalis pedis pulse-wave velocity (PWV), and via B-mode ultrasound of the common carotid intima-media (IMT). Non-fasting blood samples were collected for lipid and inflammatory marker evaluation. Linear regression models were constructed to determine the associations between extent of periodontal pocketing and vascular health, adjusting for traditional cardiovascular common risk factors. Results 273 Indigenous Australian adults were recruited and complete data was available for 269 participants (154 males), median age 39 years. Arterial stiffness (PWV) significantly increased with increasing extent of periodontal pocketing (p trend = 0.001). By contrast, carotid IMT did not differ across quartiles. Conclusions Periodontal pocketing was associated with central arterial stiffness, a marker of presymptomatic arterial dysfunction, in Indigenous Australian adults with periodontal disease.

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