Abstract
Background and Purpose - A short-term increase in dietary nitrate (NO 3 -) improves markers of vascular health via formation of nitric oxide and other bioactive nitrogen oxides. Whether this translates into long-term vascular disease risk reduction has yet to be examined. We investigated the association of vegetable-derived nitrate intake with common carotid artery intima-media thickness (CCA-IMT), plaque severity, and ischemic cerebrovascular disease events in elderly women (n=1226). Methods - Vegetable nitrate intake, lifestyle factors, and cardiovascular disease risk factors were determined at baseline (1998). CCA-IMT and plaque severity were measured using B-mode carotid ultrasound (2001). Complete ischemic cerebrovascular disease hospitalizations or deaths (events) over 14.5 years (15 032 person-years of follow-up) were obtained from the West Australian Data Linkage System. Results - Higher vegetable nitrate intake was associated with a lower maximum CCA-IMT (B=-0.015, P=0.002) and lower mean CCA-IMT (B=-0.012, P=0.006). This relationship remained significant after adjustment for lifestyle and cardiovascular risk factors (P≤0.01). Vegetable nitrate intake was not a predictor of plaque severity. In total 186 (15%) women experienced an ischemic cerebrovascular disease event. For every 1 SD (29 mg/d) higher intake of vegetable nitrate, there was an associated 17% lower risk of 14.5-year ischemic cerebrovascular disease events in both unadjusted and fully adjusted models (P=0.02). Conclusions - Independent of other risk factors, higher vegetable nitrate was associated with a lower CCA-IMT and a lower risk of an ischemic cerebrovascular disease event.
| Language | English |
|---|---|
| Pages | 1724-1729 |
| Number of pages | 6 |
| Journal | Stroke |
| Volume | 48 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 1 Jul 2017 |
Keywords
- atherosclerosis
- cardiovascular disease
- cerebrovascular disease
- nitrates
- vegetables
ASJC Scopus subject areas
- Clinical Neurology
- Cardiology and Cardiovascular Medicine
- Advanced and Specialised Nursing
Cite this
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Association of Vegetable Nitrate Intake with Carotid Atherosclerosis and Ischemic Cerebrovascular Disease in Older Women. / Bondonno, Catherine P.; Blekkenhorst, Lauren C.; Prince, Richard L.; Ivey, Kerry; Lewis, Joshua R.; Devine, Amanda; Woodman, Richard J.; Lundberg, Jon O.; Croft, Kevin D.; Thompson, Peter L.; Hodgson, Jonathan M.
In: Stroke, Vol. 48, No. 7, 01.07.2017, p. 1724-1729.Research output: Contribution to journal › Article
TY - JOUR
T1 - Association of Vegetable Nitrate Intake with Carotid Atherosclerosis and Ischemic Cerebrovascular Disease in Older Women
AU - Bondonno, Catherine P.
AU - Blekkenhorst, Lauren C.
AU - Prince, Richard L.
AU - Ivey, Kerry
AU - Lewis, Joshua R.
AU - Devine, Amanda
AU - Woodman, Richard J.
AU - Lundberg, Jon O.
AU - Croft, Kevin D.
AU - Thompson, Peter L.
AU - Hodgson, Jonathan M.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Background and Purpose - A short-term increase in dietary nitrate (NO 3 -) improves markers of vascular health via formation of nitric oxide and other bioactive nitrogen oxides. Whether this translates into long-term vascular disease risk reduction has yet to be examined. We investigated the association of vegetable-derived nitrate intake with common carotid artery intima-media thickness (CCA-IMT), plaque severity, and ischemic cerebrovascular disease events in elderly women (n=1226). Methods - Vegetable nitrate intake, lifestyle factors, and cardiovascular disease risk factors were determined at baseline (1998). CCA-IMT and plaque severity were measured using B-mode carotid ultrasound (2001). Complete ischemic cerebrovascular disease hospitalizations or deaths (events) over 14.5 years (15 032 person-years of follow-up) were obtained from the West Australian Data Linkage System. Results - Higher vegetable nitrate intake was associated with a lower maximum CCA-IMT (B=-0.015, P=0.002) and lower mean CCA-IMT (B=-0.012, P=0.006). This relationship remained significant after adjustment for lifestyle and cardiovascular risk factors (P≤0.01). Vegetable nitrate intake was not a predictor of plaque severity. In total 186 (15%) women experienced an ischemic cerebrovascular disease event. For every 1 SD (29 mg/d) higher intake of vegetable nitrate, there was an associated 17% lower risk of 14.5-year ischemic cerebrovascular disease events in both unadjusted and fully adjusted models (P=0.02). Conclusions - Independent of other risk factors, higher vegetable nitrate was associated with a lower CCA-IMT and a lower risk of an ischemic cerebrovascular disease event.
AB - Background and Purpose - A short-term increase in dietary nitrate (NO 3 -) improves markers of vascular health via formation of nitric oxide and other bioactive nitrogen oxides. Whether this translates into long-term vascular disease risk reduction has yet to be examined. We investigated the association of vegetable-derived nitrate intake with common carotid artery intima-media thickness (CCA-IMT), plaque severity, and ischemic cerebrovascular disease events in elderly women (n=1226). Methods - Vegetable nitrate intake, lifestyle factors, and cardiovascular disease risk factors were determined at baseline (1998). CCA-IMT and plaque severity were measured using B-mode carotid ultrasound (2001). Complete ischemic cerebrovascular disease hospitalizations or deaths (events) over 14.5 years (15 032 person-years of follow-up) were obtained from the West Australian Data Linkage System. Results - Higher vegetable nitrate intake was associated with a lower maximum CCA-IMT (B=-0.015, P=0.002) and lower mean CCA-IMT (B=-0.012, P=0.006). This relationship remained significant after adjustment for lifestyle and cardiovascular risk factors (P≤0.01). Vegetable nitrate intake was not a predictor of plaque severity. In total 186 (15%) women experienced an ischemic cerebrovascular disease event. For every 1 SD (29 mg/d) higher intake of vegetable nitrate, there was an associated 17% lower risk of 14.5-year ischemic cerebrovascular disease events in both unadjusted and fully adjusted models (P=0.02). Conclusions - Independent of other risk factors, higher vegetable nitrate was associated with a lower CCA-IMT and a lower risk of an ischemic cerebrovascular disease event.
KW - atherosclerosis
KW - cardiovascular disease
KW - cerebrovascular disease
KW - nitrates
KW - vegetables
UR - http://www.scopus.com/inward/record.url?scp=85020652238&partnerID=8YFLogxK
U2 - 10.1161/STROKEAHA.117.016844
DO - 10.1161/STROKEAHA.117.016844
M3 - Article
VL - 48
SP - 1724
EP - 1729
JO - Stroke
T2 - Stroke
JF - Stroke
SN - 0039-2499
IS - 7
ER -